3 documents found, page 1 of 1
Large-scale genomic analysis shows association between homoplastic genetic vari...
Ruesen, Carolien; Chaidir, Lidya; van Laarhoven, Arjan; Dian, Sofiati; Ganiem, Ahmad Rizal; Guimarães, Hanna Nebenzahl; Huynen, Martijn A.Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.
Transmissible Mycobacterium tuberculosis Strains Share Genetic Markers and Immu...
Nebenzahl-Guimaraes, Hanna; van Laarhoven, Arjan; Farhat, Maha R.; Koeken, Valerie A. C. M.; Mandemakers, Jornt J.; Zomer, AldertSuccessful transmission of tuberculosis depends on the interplay of human behavior, host immune responses, and Mycobacterium tuberculosis virulence factors. Previous studies have been focused on identifying host risk factors associated with increased transmission, but the contribution of specific genetic variations in mycobacterial strains themselves are still unknown.
Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenet...
Arts, Rob J.W.; Novakovic, Boris; ter Horst, Rob; Carvalho, Agostinho Albérico Rodrigues; Bekkering, Siroon; Lachmandas, EktaInduction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and the cholesterol synthesis pathway as indispensable for the induction of trained immunity by ß-glucan in monocytes....