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Genetically manipulated phages with improved pH resistance for oral administrat...
Nóbrega, Franklin Luzia; Costa, Ana Rita; Santos, J.; Siliakus, Melvin F.; van Lent, Jan W. M.; Kengen, Servé W. M.; Azeredo, Joana; Kluskens, LeonOrally administered phages to control zoonotic pathogens face important challenges, mainly related to the hostile conditions found in the gastrointestinal tract (GIT). These include temperature, salinity and primarily pH, which is exceptionally low in certain compartments. Phage survival under these conditions can be jeopardized and undermine treatment. Strategies like encapsulation have been attempted with rel...
Date: 2016
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Origin: RepositóriUM - Universidade do Minho