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Development and performance of the c4c national clinical trial networks for opt...

Degraeuwe, Eva; van der Geest, Tessa; Persijn, Laura; Nuytinck, Lieve; Raes, Ann; Turner, Mark; Fernandes, Ricardo M.; Vande Walle, Johan

Introduction: The high failure rate of industry-driven pediatric clinical trials leads to insufficient timely labeling of drugs in children and a lack of scientific evidence, resulting in the persistently high off-label drug use. National clinical trial networks can facilitate collaboration between sites, investigators, and experts, increasing the likelihood of successful trials. Within the conect4children (c4c...


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