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MIBiG 4.0: advancing biosynthetic gene cluster curation through global collabor...
Zdouc, Mitja M.; Blin, Kai; Louwen, Nico L. L.; Navarro, Jorge; Loureiro, Catarina; Bader, Chantal D.; Bailey, Constance B.; Barra, LenaSpecialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readabl...
Computational Applications in Secondary Metabolite Discovery (CAiSMD): an onlin...
Ntie-Kang, Fidele; Telukunta, Kiran K.; Fobofou, Serge A. T.; Chukwudi Osamor, Victor; Egieyeh, Samuel A.; Valli, Marilia [UNESP]Made available in DSpace on 2022-04-29T08:32:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01; Deutscher Akademischer Austauschdienst; We report the major conclusions of the online open-access workshop “Computational Applications in Secondary Metabolite Discovery (CAiSMD)” that took place from 08 to 10 March 2021. Invited speakers from academia and industry and about 200 registered participants f...
Inhibitory activity of plumbagin produced by Drosera intermedia on food spoilag...
Grevenstuk, Tomás; Gonçalves, Sandra; Domingos, Telma; Quintas, Célia; van der Hooft, Justin J. J.; Vervoort, Jacques; Romano, AnabelaBackground: The aim of this study was to investigate the growth-inhibiting efficacy of Drosera intermedia extracts (water, methanol and n-hexane) against four food spoilage yeasts and five filamentous fungi strains responsible for food deterioration and associated with mycotoxin production, in order to identify potential antimycotic agents. Results: The n-hexane extract showed a broad activity spectrum against ...
Iridoid and caffeoyl phenylethanoid glycosides of the endangered carnivorous pl...
Grevenstuk, Tomás; van der Hooft, Justin J. J.; Vervoort, Jacques; de Waard, Pieter; Romano, AnabelaThis work reports for the first time the identification of the major compounds of Pinguicula lusitanica, an endangered carnivorous plant species, using minimal amounts of plant material. A methanol extract was prepared from in vitro cultured plantlets and analyzed by HPLC-SPE-NMR/HPLC-MS. Three iridoid and five caffeoyl phenylethanoid glycosides were identified. These groups of natural compounds were previously...