2 documents found, page 1 of 1
The GAIN Registry — a New Prospective Study for Patients with Multi-organ Autoi...
Staus, P; Rusch, S; El-Helou, S; Müller, G; Krausz, M; Geisen, U; Caballero-Oteyza, A; Krüger, R; Bakhtiar, S; Lee-Kirsch, MA; Fasshauer, M; Baumann, UPatient registries are a very important and essential tool for investigating rare diseases, as most physicians only see a limited number of cases during their career. Diseases of multi-organ autoimmunity and autoinflammation are especially challenging, as they are characterized by diverse clinical phenotypes and highly variable expressivity. The GAIN consortium (German multi-organ Auto Immunity Network) develop...
Targeted Gene Panel Sequencing for Early-onset Inflammatory Bowel Disease and C...
Petersen, BS; August, D; Abt, R; Alddafari, M; Atarod, L; Baris, S; Bhavsar, H; Brinkert, F; Buchta, M; Bulashevska, A; Chee, R; Cordeiro, AI; Dara, NBackground: In contrast to adult-onset inflammatory bowel disease (IBD), where many genetic loci have been shown to be involved in complex disease etiology, early-onset IBD (eoIBD) and associated syndromes can sometimes present as monogenic conditions. As a result, the clinical phenotype and ideal disease management in these patients often differ from those in adult-onset IBD. However, due to high costs and the...