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Localized cancer photodynamic therapy approach based on core–shell electrospun ...

Photodynamic therapy (PDT) has been considered a promising treatment for several types of cancer, including cervical cancer. Localized drug delivery systems (DDSs) based on nanofibers produced by electrospinning have emerged as a powerful platform to carry and deliver photosensitizers (PSs) onto or adjacent to the tumor site, thereby promoting higher therapeutic efficacy and reducing the side effects to healthy...

Enhancing bacterial photodynamic inactivation through combined action of potass...

Infectious diseases remain a leading cause of death all around the world. Over the last three decades, the alarming and escalating emergence of antibiotic-resistant bacterial strains has caused some concern among the scientific community [1,2]. Photodynamic inactivation (PDI) emerges as an alternative for inactivating microorganisms, including bacteria [1–3]. The use of phthalocyanine (Pc) derivatives as photos...

Deep Eutectic Solvents as alternative solvents in Antimicrobial Photodynamic Th...

Photodynamic inactivation of a RNA-virus model using water-soluble β-octa-Subst...

Among the various groups of microorganisms, viruses have generally a greater capacity for mutation, especially RNA viruses, as was demonstrated by SARS-CoV2 virus mutations. This high mutation rate promotes the development of their resistance to traditional antivirals and establishes the resistance behaviour in virus populations, decreasing their susceptibility to these drugs. In this context, the photodynamic ...

Investigation of the potential of deep eutectic solvents (DES) as alternative s...

Antimicrobial Photodynamic Therapy (aPDT) is gaining recognition as an effective approach for the photoinactivation of a broad spectrum of microorganisms [1,2]. Due to their apolar behavior, photosensitizers (PS) often have low solubility in aqueous media requiring the use of toxic organic solvents that are incompatible with their application in the field [4]. In this study, the potential of Deep Eutectic Solve...

Interfacial assembly of zinc(II) phthalocyanines on graphene oxide (GO): stable...

Hypothesis The aggregation of phthalocyanines (Pcs) enfeebles their suitability as G-quadruplex (G4) ligands over time. It is hypothesized that the interfacial assembly of Pcs on graphene oxide (GO) influences intermolecular interactions, thereby affecting their physicochemical properties and inducing stabilization of Pcs in solution. Hence, the stacking of Pcs on GO could be tuned to create nanosystems with th...

Multicharged Phthalocyanines as Selective Ligands for G-Quadruplex DNA Structures

The stabilization of G-Quadruplex DNA structures by ligands is a promising strategy for telomerase inhibition in cancer therapy since this enzyme is responsible for the unlimited proliferation of cancer cells. To assess the potential of a compound as a telomerase inhibitor, selectivity for quadruplex over duplex DNA is a fundamental attribute, as the drug must be able to recognize quadruplex DNA in the presence...

Crystal structures of the water and acetone monosolvates of bis[4′-(pyridin-4-y...

The crystal structures of bis[4′-(pyridin-4-yl)-2,2′:6′,2″-terpyridine]mangan-ese(II) bis(hexafluoridophosphate) monohydrate, [Mn(C20H14N4)2](PF6)2·-H2O, (1), and bis[4′-(pyridin-4-yl)-2,2′:6′,2″-terpyridine]manganese(II) bis-(hexafluoridophosphate) acetone monosolvate, (2), [Mn(C20H14N4)2]-(PF6)2·CH3COCH3, are described. At 150 K, (1) and (2) have monoclinic (P21/c) and orthorhombic (C2221) symmetries, respect...

Inverted methoxypyridinium phthalocyanines for PDI of pathogenic bacteria

Phthalocyanines (Pc) are photoactive molecules that can absorb and emit light in a large range of the UV-Vis spectrum with recognized potential for medical applications. Considering the biomedical applications an important limitation of these compounds is their low solubility in water. The use of suitable pyridinium groups on Pc is a good strategy to solve this drawback and to make them more effective to photoi...