List of publications
DJ-1 neuronal rescue under oxidative stress: implications for Parkinson's disease
The current list of publications was generated automatically by the RCAAP portal on 2025-06-19. This list contains all the publications deposited in the repositories from the RCAAP network repositories to which was attributed the funding identifier: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/124354.
This list is not updated automatically and refers only to the contents identified until the date of its generation. To fulfil with the obligations associated with the open rightsAccess policies from Fundação para a Ciência e a Tecnologia, please mention this link in the scientific reports required by this funding agency.
Project/scholarship information
| Name of project/scholarship | DJ-1 neuronal rescue under oxidative stress: implications for Parkinson's disease |
| Description | Parkinson’s Disease (PD) is one of the major neurodegenerative disorders, characterized by massive loss of dopaminergic neurons, leading to severe motor impairment. DJ-1 was identified as a causative gene of familial early onset PD, later confirmed in animal models. Although the physiological functions of DJ-1 are not fully understood, several lines of evidence suggest that it is involved in protection against oxidative stress, the proposed cause of death of dopaminergic neurons in PD. The mechanism responsible for DJ-1-mediated neuronal rescue was thought to be direct scavenging of reactive oxygen species (ROS), however, recent data suggests that activation of survival and repression of stress- and apoptosis-related signaling pathways play the most significant role. Additional studies identified direct binding of DJ-1 to several proteins, modulating their activity (ASK-1, alfa-Synuclein, TH and L-DOPA Decarboxilase). By extensively studying DJ-1 functions, new perspectives will be opened for PD. As a result, future work may concentrate on the design of small molecules that may easily cross the blood-brain barrier and compensate for the loss of DJ-1 in patients, by artificially modulating the relevant signaling pathways identified. |
| Funder | FCT - Fundação para a Ciência e a Tecnologia, I.P. |
| Funding program | 5876-PPCDTI |
| Project/scholarship ID | 124354 |
| Reference | PTDC/NEU-NMC/0205/2012 |
| FundRef URI | http://www.fct.pt/apoios/projectos/consulta/vglobal_projecto.phtml.en?idProjecto=124354&idElemConcurso=7426 |
| Start date | 2013-05-01 |
| End date | 2015-09-30 |
| Funding amount | 172,670.00 € |
Report information
Documents
| Co-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair | Gomes, Eduardo D.; Mendes, Sofia Silva; Silva, Rita Catarina Assunção Ribeiro; Teixeira, Fábio Gabriel Rodrigues; Pires, Ana O.; Anjo, Sandra I.; Manadas, Bruno; Leite-Almeida, Hugo; Gimble, Jeffrey M.; Sousa, Nuno; Lepore, Angelo C.; Silva, Nuno André Martins; Salgado, A. J. | Open Access | Journal article | 2018 | rum | http://hdl.handle.net/1822/57852 |
| Oxidative Stress Biomarkers: Closer to early diagnosis of neurodegenerative diseases? | Salvado, Ruben Joel Bispo | Open Access | Master thesis | 2017 | estudogl | https://hdl.handle.net/10316/83037 |
| Development and validation of an analytical method for quantification of dopamine metabolism in plasma samples by LC-MS/MS | Dias, Ana Sofia Abrantes | Open Access | Master thesis | 2017 | estudogl | https://hdl.handle.net/10316/83176 |
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