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Diabetes Mellitus is a chronic disease characterizes by the absence of insulin production by the body or the inability of their effectively use. WHO estimated that 8.5% of adults had diabetes in 2014 and the prevalence of the disease has been rising. Objectives: The study aimed to determine prevalence of diabetics, the frequency of glycemic control, identify change in eating habits and physical exercise, characterize the pharmacological therapy and verify the therapy adherence in diabetics of northeast Portugal. Methods: A descriptive and cross-sectional study was performed by applying an interview to 202 adult diabetics of Trás-os-Montes region (Portugal), based on a questionnaire, with MAT scale (measure of adherence to therapy) validated for the Portuguese population (Delgado & Lima, 2001). Results: The results showed 73,8% and 26,2% diabetics of type 1 and type 2, respectively. Most of the total diabetics (38,1%, 77) have controlled the glycemic once a day and 122 (60.4%) have modified eating habits (92,6% have reduced the sugar consumption and 53,3% have reduced the carbohydrates consumption). Additionally, 89.7% indicate the increased frequency of physical activity. Concerning their quality life, 44,6% consider it as moderate. The drugs more used were metformin (63) and insulin (52) and the use of incretin mimetics was low (13.9%, 28), with more expression of the association of metformin and vildagliptin (21). The prevalence of diabetics adherents to therapy was 92,6%. Conclusions: The majority of diabetics adhered to therapy and the use of incretin mimetics remains with low significance.