Author(s):
Freitas, Emanuelle Dantas de, 1988- ; Rosa, Paulo César Pires, 1976- ; Silva, Meuris Gurgel Carlos da, 1955- ; Vieira, Melissa Gurgel Adeodato, 1979-
Date: 2021
Persistent ID: https://hdl.handle.net/20.500.12733/1655403
Origin: Oasisbr
Subject(s): Naproxeno; Naproxen; Sericin and alginate blend; Experimental design; Modified release formulation; Artigo original; Naproxeno; Naproxeno; Naproxen; Naproxen; Sericin and alginate blend; Sericin and alginate blend; Experimental design; Experimental design; Modified release formulation; Modified release formulation; Artigo original; Artigo original
Description
Agradecimentos: The authors are thankful for the financial support earned by CNPq (Grant number 470615/2013-3) and Fapesp (Grant number 2015/13505-9 and 2016/05007-1) besides the donation of silkworm cocoons carried out by Bratac Silk Mills Company
Abstract: The polymeric blend of sericin and alginate has already shown good results for the incorporation of naproxen, achieving delayed and prolonged release. Thus, in this paper, it was aimed to optimize formulations of naproxen-loaded sericin and alginate blend, using the technique of experimental design. Initial amounts of alginate and drug were evaluated on entrapment efficiency, drug loading and time to release 85% of drug (t85). Efficiency was not affected statistically, while drug loading was higher for higher amounts of naproxen. In addition, the longest release times were achieved for greater amounts of drug and/or alginate, and the presence of sericin proved to be essential to extend the release of naproxen. The analytical characterizations of the particles showed the incorporation of the drug mainly in its original crystalline form, with part being physically mixed with the matrix. In addition, both the matrix and the drug loaded matrix demonstrated biocompatibility with HaCaT cell line
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
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