Author(s):
Morgon, Nelson Henrique, 1964-
Date: 2019
Persistent ID: https://hdl.handle.net/20.500.12733/1671032
Origin: Oasisbr
Subject(s): Espectrometria de massa; Análise espectral; Dicroísmo circular; Células; Mass spectrometry; Spectrum analysis; Circular dichroism; Cells; Organic compounds; Artigo original; Espectrometria de massa; Espectrometria de massa; Análise espectral; Análise espectral; Dicroísmo circular; Dicroísmo circular; Células; Células; Mass spectrometry; Mass spectrometry; Spectrum analysis; Spectrum analysis; Circular dichroism; Circular dichroism; Cells; Cells; Organic compounds; Organic compounds; Artigo original; Artigo original
Description
Agradecimentos: The authors would like to dedicate this work to Prof. Dra. Maria Lúcia Belém-Pinheiro from UFAM, Brazil, for her contributions for more than 30 years to the study of the chemistry of natural product from the Amazon region. We are also grateful to Prof. Dr. A. C. Webber of UFAM for botanical identification, M. Sc. Renan Galaverna from UNICAMP, Brazil, for the ECD measurements, and Central Analítica (UFAM) for the NMR and MS analysis. We acknowledge the funding foundations FAPEAM, CAPES, CNPq, FINEP, and FAPESB
In addition to seven known alkaloids (2, 6-11) and 1,2,4-trimethoxybenzene (1), three isoquinoline-derived alkaloids (3-5), namely, duguetinine (3), a compound based on an unprecedented oxahomoaporphine scaffold, and two new 8-oxohomoaporphine alkaloids, duguesuramine (4) and 11-methoxyduguesuramine (5), and a new asarone-derived phenylpropanoid (10) were isolated from the bark of Duguetia surinamensis. The isolation workflow was guided by HPLC-HRESIMS/MS and molecular networking-based analyses. Twenty-four known alkaloids were dereplicated from the D. surinamensis alkaloid-rich fraction network and were assigned by manual MS/MS interpretation. Their cytotoxic potential was evaluated
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DA BAHIA - FAPESB
COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO AMAZONAS - FAPEAM
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