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This study aimed to verify the relationship between anthropometric measures (AM), blood pressure (BP) and cardiorespiratory fitness (CRF), physical activity (PA), sedentary behaviour (SB), predicted BMI z-score, waist circumference (WC) and waist-to-height ratio (WHtR) variance. A total of 245 children (8.90 ± .80years-old) were recruited from a Portuguese school. WHtR was classified according the reference ≥ 0.5. WC was measured above iliac crest. BP was assessed using a sphygmomanometer, and CRF using 20-m run test. PA and SB were assessed by accelerometers (Actigraph GT3x) and by questionnaire. Participants did not meet recommendations on PA. CRF and vigorous PA (VPA) were inversely correlated with AM. Moderate and vigorous PA were positively correlated with CRF. CRF was inversely correlated with systolic and diastolic BP. CRF and PA explained BMI z-score variance. WC and WHtR variance was predicted by CRF. These results emphasize the importance of international recommendations for PA with the purpose of developing CRF. A new emphasis should be given to CRF and interdisciplinary approaches in international recommendations. This should provide new health implications for primary care providers and school services.