Document details

Impact of Infrasound Exposure and Streptozotocin-Induced Glucose Intolerance on Bone Composition in Wistar Rats.

Author(s): Zagalo, Luísa ; Pereira, Gonçalo ; Casal, Diogo ; Gonçalves, Luísa L ; Zagalo, Carlos ; Oliveira, Maria João ; Oliveira, Pedro ; Brito, José A A

Date: 2024

Persistent ID: http://hdl.handle.net/10400.17/5247

Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE

Subject(s): HSJ CPR; Animals; Rats; Male; Bone and Bones / metabolism; Calcium* / metabolism; Diabetes Mellitus; Experimental* / chemically induced; Experimental* / metabolism; Glucose Intolerance / metabolism; Phosphorus* / metabolism; Wistar*; Sound / adverse effects; Spectrometry; X-Ray Emission; Streptozocin*; Tibia / metabolism; HSJ CPR; HSJ CPR; Animals; Animals; Rats; Rats; Male; Male; Bone and Bones / metabolism; Bone and Bones / metabolism; Calcium* / metabolism; Calcium* / metabolism; Diabetes Mellitus; Diabetes Mellitus; Experimental* / chemically induced; Experimental* / chemically induced; Experimental* / metabolism; Experimental* / metabolism; Glucose Intolerance / metabolism; Glucose Intolerance / metabolism; Phosphorus* / metabolism; Phosphorus* / metabolism; Wistar*; Wistar*; Sound / adverse effects; Sound / adverse effects; Spectrometry; Spectrometry; X-Ray Emission; X-Ray Emission; Streptozocin*; Streptozocin*; Tibia / metabolism; Tibia / metabolism


Description

The elemental composition of chemical elements can vary between healthy and diseased tissues, providing essential insights into metabolic processes in physiological and diseased states. This study aimed to evaluate the calcium (Ca) and phosphorus (P) levels in the bones of rats with/without streptozotocin-induced diabetes and/or exposure to infrasound. X-ray fluorescence spectroscopy was used to determine the concentrations of Ca and P in Wistar rat tibiae samples.The results showed a significant decrease in bone P concentration in streptozotocin-induced diabetic rats compared to untreated animals. Similarly, the Ca/P ratio was higher in the streptozotocin-induced diabetic group. No significant differences were observed in bone Ca concentration between the studied groups or between animals exposed and not exposed to infrasound.Moreover, streptozotocin-induced diabetic rats had lower bone P concentration but unaltered bone Ca concentration compared to untreated rats. Infrasound exposure did not impact bone Ca or P levels. The reduced bone P concentration may be associated with an increased risk of bone fractures in diabetes.

Document Type Text
Language English
Contributor(s) Repositório da Unidade Local de Saúde São José
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