Autor(es):
Santos, Washington Luis Conrado dos ; Jesus, E. E. ; Silva, M. Paranhos ; Pereira, A. M. ; Santos, J. C. ; Baleeiro, C. O. ; Nascimento, E. G. ; Moreira, E. D. ; Oliveira, G. G. S. ; Carvalho, Lain Carlos Pontes de
Data: 2012
Origem: Oasisbr
Assunto(s): Leishmanin skin test; Canine visceral leishmaniasis; Leishmania chagasi; Leishmania infantum; Spleen; Immunoglobulin isotypes; Leishmanin skin test; Leishmanin skin test; Canine visceral leishmaniasis; Canine visceral leishmaniasis; Leishmania chagasi; Leishmania chagasi; Leishmania infantum; Leishmania infantum; Spleen; Spleen; Immunoglobulin isotypes; Immunoglobulin isotypes
Descrição
Acesso restrito: Texto completo. p. 251-259
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Made available in DSpace on 2012-06-14T11:22:35Z (GMT). No. of bitstreams: 1 __ac.els-cdn.com_S016524...a6bbdc409521bb03131f24171e0e5.pdf: 159828 bytes, checksum: 302bc73c6665de449a961f1d06af8bd2 (MD5) Previous issue date: 2008
Associations among parameters commonly used as markers of infection by Leishmania sp., or of susceptibility to visceral leishmaniasis, were investigated in 325 stray dogs from an area where this disease is endemic. Evidence of infection (presence of Leishmania in splenic cultures, positive leishmanin skin test (LST) or detection of anti-Leishmania antibody activity in the serum) was found in 57% of the animals. Both evidence of weight loss (x2-test, P = 0.0005) and presence of specific antibody activity in the serum (x2-test, P < 0.0001) were directly associated with positive splenic culture. The frequencies of animals with positive splenic culture were directly correlated with the intensities of antibody activity in the serum as measured by ELISA (relative risk of 3.4 for animals with moderate antibody levels and relative risk of 8.43 for animals with high-antibody levels). A negative association was observed between positive leishmanin skin test results and emaciation (x2, P = 0.0089). Furthermore, animals with positive splenic cultures and negative leishmanin skin test results had higher levels of total serum IgG (Kruskal–Wallis test, P = 0.001) and IgG2 (Kruskal–Wallis test, P = 0.05) than animals with negative splenic cultures, and were more emaciated than animals with negative LST results and positive splenic cultures. The data presented herein suggest that associating these common parameters may improve their performance in predicting susceptibility to canine visceral leishmaniasis.
