Autor(es): Alvarez, Matheus [UNESP] ; Miranda, Diana Rodrigues de Pina [UNESP] ; Romeiro, Fernando Gomes [UNESP] ; Duarte, Sergio Barbosa ; Arruda Miranda, Jose Ricardo de [UNESP]
Data: 2015
Identificador Persistente: http://hdl.handle.net/11449/117324
Origem: Oasisbr
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Background: Hepatocellular carcinoma is a primary tumor of the liver and involves different treatment modalities according to the tumor stage. After local therapies, the tumor evaluation is based on the mRECIST criteria, which involves the measurement of the maximum diameter of the viable lesion. This paper describes a computed methodology to measure through the contrasted area of the lesions the maximum diameter of the tumor by a computational algorithm.Methods: 63 computed tomography (CT) slices from 23 patients were assessed. Non-contrasted liver and HCC typical nodules were evaluated, and a virtual phantom was developed for this purpose. Optimization of the algorithm detection and quantification was made using the virtual phantom. After that, we compared the algorithm findings of maximum diameter of the target lesions against radiologist measures.Results: Computed results of the maximum diameter are in good agreement with the results obtained by radiologist evaluation, indicating that the algorithm was able to detect properly the tumor limits. A comparison of the estimated maximum diameter by radiologist versus the algorithm revealed differences on the order of 0.25 cm for large-sized tumors (diameter > 5 cm), whereas agreement lesser than 1.0 cm was found for small-sized tumors.Conclusions: Differences between algorithm and radiologist measures were accurate for small-sized tumors with a trend to a small decrease for tumors greater than 5 cm. Therefore, traditional methods for measuring lesion diameter should be complemented non-subjective measurement methods, which would allow a more correct evaluation of the contrast-enhanced areas of HCC according to the mRECIST criteria.
Univ Estadual Paulista, UNESP, Dept Fis & Biofis, Inst Biociencias Botucatu, BR-18618000 Botucatu, SP, Brazil
Univ Estadual Paulista, UNESP, Fac Med Botucatu, Dept Doencas Trop & Diagnost Imagem, BR-18618000 Botucatu, SP, Brazil
Univ Estadual Paulista, UNESP, Dept Clin Med, Fac Med Botucatu, BR-18618000 Botucatu, SP, Brazil
CBPF MCT, Ctr Brasileiro Pesquisas Fis, BR-22290180 Rio De Janeiro, Brazil
Univ Estadual Paulista, UNESP, Dept Fis & Biofis, Inst Biociencias Botucatu, BR-18618000 Botucatu, SP, Brazil
Univ Estadual Paulista, UNESP, Fac Med Botucatu, Dept Doencas Trop & Diagnost Imagem, BR-18618000 Botucatu, SP, Brazil
Univ Estadual Paulista, UNESP, Dept Clin Med, Fac Med Botucatu, BR-18618000 Botucatu, SP, Brazil
