Author(s):
Borges, Felipe Azevedo [UNESP] ; Bolognesi, Luis Felipe Cesar [UNESP] ; Trecco, Alberto [UNESP] ; Drago, Bruno de Camargo [UNESP] ; Arruda, Larisa Baldo de [UNESP] ; Lisboa Filho, Paulo Noronha [UNESP] ; Pierri, Elaise Gonçalves [UNESP] ; Graeff, Carlos Frederico de Oliveira [UNESP] ; Santos, André Gonzaga dos [UNESP] ; Miranda, Matheus Carlos Romeiro [UNESP] ; Herculano, Rondinelli Donizetti [UNESP]
Date: 2015
Persistent ID: http://hdl.handle.net/11449/123626
Origin: Oasisbr
Subject(s): Casearia sylvestris Swartz; Latex membrane; biomaterials; Casearia sylvestris Swartz; Casearia sylvestris Swartz; Latex membrane; Latex membrane; biomaterials; biomaterials
Description
Made available in DSpace on 2015-05-15T13:30:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2014Bitstream added on 2015-05-15T13:56:30Z : No. of bitstreams: 1 ISSN2090-8733-2014-241297-2014.pdf: 1900488 bytes, checksum: 79b2d280b31cc2fdec2c80b18538e0ed (MD5)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Natural rubber latex (NRL) from Hevea brasiliensis has showed interesting biomedical properties as improving wound healing, cell adherence, tissue formation, and angiogenesis. It is used for biosynthesis of nanoparticles, sensors and prosthesis and for drug delivery systems (for drugs, plant extracts, and nanoparticles). To enhance its wound healing properties was incorporated Casearia sylvestris Swartz extract, whose pharmacological activity includes anti-inflammatory, analgesic, antiseptic, antiulcer, and antitumor due to its casearins and phenols. Results showed the prolonged release of its compounds (35 days) and the mechanism of release is super case II ( > 1) by Korsmeyer-Peppas model. Although SEM shows different sizes of clusters at the surface, the release is homogeneous through the biomembrane. FTIR shows no interaction between the matrix and the extract, with computation of the presence of some casearins.
Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Faculdade de Araraquara - Ciências Farmacêuticas, Centro, CEP 14801902, SP, Brasil
Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Ciências Biológicas, Faculdade de Ciências e Letras de Assis
Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas de Araraquara
Universidade Estadual Paulista Júlio de Mesquita Filho. Departamento de Física, Faculdade de Ciências de Bauru
Universidade Estadual Paulista Júlio de Mesquita Filho, Instituto de Química de Araraquara
FAPESP: 2012/08007-1
FAPESP: 2011/17411-8
