Author(s):
Murbach, Heitor Dias [UNESP] ; Ogawa, Guilherme Jaques [UNESP] ; Borges, Felipe Azevedo [UNESP] ; Miranda, Matheus Carlos Romeiro [UNESP] ; Lopes, Rute [UNESP] ; Barros, Natan Roberto [UNESP] ; Mazalli, Alexandre Vinicius Guedes [UNESP] ; Silva, Rosangela Gonçalves da [UNESP] ; Cinman, José Luis Ferreira [UNESP] ; Drago, Bruno de Camargo [UNESP] ; Herculano, Rondinelli Donizetti [UNESP]
Date: 2015
Persistent ID: http://hdl.handle.net/11449/123627
Origin: Oasisbr
Subject(s): ciprofloxacin; natural rubber; Drug Delivery System; biomembranas; ciprofloxacin; ciprofloxacin; natural rubber; natural rubber; Drug Delivery System; Drug Delivery System; biomembranas; biomembranas
Description
Made available in DSpace on 2015-05-15T13:30:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2014Bitstream added on 2015-05-15T13:56:30Z : No. of bitstreams: 1 ISSN1687-8787-2014-2014-01-07.pdf: 2534524 bytes, checksum: 8cf2c9bfb6cc4cd0816768632af7b502 (MD5)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação para o Desenvolvimento da UNESP (FUNDUNESP)
Pró-Reitoria de Pesquisa da UNESP (PROPe)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Natural rubber latex (NRL) from Hevea brasiliensis is easily manipulated, low cost, is of can stimulate natural angiogenesis and cellular adhesion, is a biocompatible, material and presents high mechanical resistance. Ciprofloxacin (CIP) is a synthetic antibiotic (fluoroquinolone) used in the treatment of infection at external fixation screws sites and remote infections, and this use is increasingly frequent in medical practice. The aim of this study was to develop a novel sustained delivery system for CIP based on NRL membranes and to study its delivery system behavior. CIP was found to be adsorbed on the NRL membrane, according to results of energy dispersive X-ray spectroscopy. Results show that the membrane can release CIP for up to 59.08% in 312 hours and the mechanism is due to super case II (non-Fickian). The kinetics of the drug release could be fitted with double exponential function X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy shows some interaction by hydrogen bound, which influences its mechanical behavior.
Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Faculdade de Araraquara - Ciências Farmacêuticas, Centro, CEP 14801902, SP, Brasil
Biological Sciences Department, Faculty of Language & Sciences, São Paulo State University (UNESP), 2100 Dom Antonio Avenue, 19806-900 Assis, SP, Brazil
Chemistry Institute, São Paulo State University, 55 Professor Francisco Degni Street, 14800-060 Araraquara, SP, Brazil
Physics Department, Faculty of Sciences, São Paulo State University, 14-01 Engenheiro Luiz Edmundo Carrijo Coube Avenue, 17033-360 Bauru, SP, Brazil
FAPESP: 2011/17411-8
