Autor(es): Jardim Júnior, Élerson Gaetti [UNESP] ; Ciesielski, Francisco Isaak Nicolas [UNESP] ; Sousa, Fátima Regina Nunes de [UNESP] ; Nwaokorie, Francisca ; Schweitzer, Christiane Marie [UNESP] ; Avila-Campos, Mario Júlio
Data: 2013
Identificador Persistente: http://hdl.handle.net/11449/15629
Origem: Oasisbr
Assunto(s): Radiotherapy; Cancer; Enterobacteriaceae; Prevalence; Radiotherapy; Radiotherapy; Cancer; Cancer; Enterobacteriaceae; Enterobacteriaceae; Prevalence; Prevalence
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
The aim of this study was to evaluate the occurrence of yeasts, pseudomonads and enteric bacteria in the oral cavity of patients undergoing radiotherapy (RT) for treatment of head and neck cancer. Fifty patients receiving RT were examined before, during and 30 days after RT. Saliva, mucosa, and biofilm samples were collected and microorganisms were detected by culture and polymerase chain reaction (PCR). The most prevalent yeasts in patients submitted to RT were Candida albicans, C. tropicalis, C. krusei, C. glabrata and C. parapsilosis. Citrobacter, Enterobacter, Enterococcus, Klebsiella, Proteus, and Pseudomonas were the most frequently cultivated bacteria. Before RT, targeted bacteria were cultivated from 22.2% of edentulous patients and 16.6% of dentate patients; 30 days after RT, these microorganisms were recovered from 77.8% edentulous and 46.8% dentate patients. By PCR, these microorganisms were detected from all edentulous patients, 78.1% of dentate patients. The presence of Gram-negative enteric roads and fungi was particularly frequent in patients presenting mucositis level III or IV. Modifications in the oral environment due to RT treatment seem to facilitate the colonization of oral cavity by members of family Enterobacteriaceae, genera Enterococcus and Candida.
Universidade Estadual Paulista Faculdade de Odontologia Departamento de Patologia e Propedêutica Clínica
University of Lagos College of Medicine Department of Medical Microbiology and Parasitology
Universidade Estadual Paulista Faculdade de Engenharia Departamento de Matemática
Universidade de São Paulo Instituto de Ciências Biomédicas Departamento de Microbiologia
Universidade Estadual Paulista Faculdade de Odontologia Departamento de Patologia e Propedêutica Clínica
Universidade Estadual Paulista Faculdade de Engenharia Departamento de Matemática
FAPESP: 07/54851-0
