Author(s):
Azuma, Mariane Maffei [UNESP] ; Gomes-Filho, João Eduardo [UNESP] ; Cardoso, Carolina de Barros Morais [UNESP] ; Pipa, Camila Barbosa [UNESP] ; Narciso, Luis Gustavo [UNESP] ; Bomfim, Suely Regina Mogami [UNESP] ; Jacinto, Rogério de Castilho [UNESP] ; Cintra, Luciano Tavares Angelo [UNESP]
Date: 2018
Persistent ID: http://hdl.handle.net/11449/176451
Origin: Oasisbr
Subject(s): Apical periodontitis; Cholesterol levels; Lipid profile; Omega 3 fatty acids; Triglyceride levels; Apical periodontitis; Apical periodontitis; Cholesterol levels; Cholesterol levels; Lipid profile; Lipid profile; Omega 3 fatty acids; Omega 3 fatty acids; Triglyceride levels; Triglyceride levels
Description
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
The aim of this study was to evaluate the influence of the prophylactic and therapeutic supplementation with omega 3 polyunsaturated fatty acids (ω-3 PUFAs) on the lipid profile and periapical bone resorption in rats with apical periodontitis. Forty male rats were divided into groups: control rats (C), rats treated with ω-3 PUFAs (C+O), rats with pulp exposure-induced apical periodontitis (AP), and rats with AP treated with ω-3 PUFAs (AP+O). The administration of ω-3 PUFAs was carried out orally once a day for 15 days before pulp exposure and, subsequently, for an additional 30 days after pulp exposure. AP was induced by exposing pulpal tissues to the oral environment. The samples were collected after 30 days. Triglycerides and cholesterol levels were enzymatically measured using the Trinder method. The jaws were collected and submitted for histological analysis. Two-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at p<0.05. The triglyceride levels of the AP group were significantly higher than those of the C, C+O and AP+O groups (p<0.05). However, the difference in the cholesterol levels among the groups was not significant (p>0.05). Rats with AP showed larger areas of bone resorption as well as higher inflammatory intensity compared with rats with AP supplemented with ω-3 PUFAs. It may be concluded that the presence of multiple AP foci increased the triglyceride levels. In addition, omega 3 supplementation might reduce these levels in rats with AP, as well as the bone resorption areas of periapical tissues.
Endodontics Araçatuba Dental School UNESP-Universidade Estadual Paulista
Clinic and Surgery and Animal Reproduction Araçatuba School of Veterinary Medicine UNESP-Universidade Estadual Paulista
Endodontics Araçatuba Dental School UNESP-Universidade Estadual Paulista
Clinic and Surgery and Animal Reproduction Araçatuba School of Veterinary Medicine UNESP-Universidade Estadual Paulista
FAPESP: 2013/26390-0
FAPESP: 2015/03054-0
