Author(s):
De Araújo Júnior, Adalberto M. [UNESP] ; Braido, Guilherme [UNESP] ; Saska, Sybele [UNESP] ; Barud, Hernane S. [UNESP] ; Franchi, Leonardo P. ; Assunção, Rosana M.N. ; Scarel-Caminaga, Raquel M. [UNESP] ; Capote, Ticiana S.O. [UNESP] ; Messaddeq, Younès [UNESP] ; Ribeiro, Sidney J.L. [UNESP]
Date: 2018
Persistent ID: http://hdl.handle.net/11449/177536
Origin: Oasisbr
Subject(s): Cytotoxicity; Genotoxicity; Mutagenicity; Regenerated cellulose; Scaffold; Tissue repair; Cytotoxicity; Cytotoxicity; Genotoxicity; Genotoxicity; Mutagenicity; Mutagenicity; Regenerated cellulose; Regenerated cellulose; Scaffold; Scaffold; Tissue repair; Tissue repair
Description
Made available in DSpace on 2018-12-11T17:25:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-01-20
Regenerated cellulose scaffolds (RCS) may be used as alloplastic materials for tissue repair. In this work, the RCS were obtained by viscose process and characterized by scanning electron microscopy (SEM), wide angle X-ray diffraction (WAXD), Fourier transform infrared spectroscopy (FTIR) and thermogravimetry analysis (TG). In vitro enzymatic degradation assay and toxicological assays were also evaluated. The physicochemical characterizations revealed the formation of a porous material with distinct thermal profile and crystallinity compared to pristine cellulose pulp. Enzymatic degradation assay revealed that lysozyme showed a mildest catalytic action when compared to cellulase, Tricoderma reesei (Tr). Nevertheless, both enzymes were efficient for degrading the RCS. RCS did not show cytotoxicity, mutagenic or genotoxic effects. The systematically characterization of this work suggests that RCS presented distinct features that make it a viable material for future studies related to the development of scaffolds for biological applications.
Institute of Chemistry, São Paulo State University, UNESP, PO Box 355
Dental School at Araraquara, São Paulo State University, UNESP, Rua Humaitá, 1680
Laboratório de Química Medicinal e Medinica Regenerativa (QUIMMERA), Centro Universitário de Araraquara (UNIARA)
Ribeirão Preto Medical School, University of São Paulo, USP, Av. Bandeirantes
Faculdade de Ciências Integradas Do Pontal, Universidade Federal de Uberlândia, Campus Do Pontal, Rua Vinte, 1600
Institute of Chemistry, São Paulo State University, UNESP, PO Box 355
Dental School at Araraquara, São Paulo State University, UNESP, Rua Humaitá, 1680
