Author(s):
Vieira, Ivy Rafacho [UNESP] ; Fernandes, Reginaldo Keller [UNESP] ; Rodrigues, Daniela Ramos [UNESP] ; Gorgulho, Carolina Mendonça [UNESP] ; Kaneno, Ramon [UNESP] ; Soares, Ângela Maria Victoriano Campos [UNESP]
Date: 2019
Persistent ID: http://hdl.handle.net/11449/188221
Origin: Oasisbr
Subject(s): dendritic cells; fungicidal activity; H 2 O 2; Paracoccidioides brasiliensis; TLR9; dendritic cells; dendritic cells; fungicidal activity; fungicidal activity; H 2 O 2; H 2 O 2; Paracoccidioides brasiliensis; Paracoccidioides brasiliensis; TLR9; TLR9
Description
Made available in DSpace on 2019-10-06T16:01:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-10-01
Microorganisms killing by dendritic cells (DCs) is an important effector mechanism during innate immune response, as it can avoid dissemination of infection during migration of these cells toward draining lymph nodes. However, this function depends on pattern recognition receptors (PRRs) to which the microorganism will bind in these cells. Regarding this, TLR9 activation, by stimulating the oxidative metabolism, induces increase in microbicidal activity of these cells. Accordingly, we showed that DCs treatment with a TLR9 agonist results in an increase in fungicidal activity of these cells against the fungus Paracoccidioides brasiliensis (Pb), which however, was not associated to higher H 2 O 2 levels.
Department of Microbiology and Immunology Biosciences Institute São Paulo State University - UNESP, Distrito de Rubiao Junior S/N
Department of Microbiology and Immunology Biosciences Institute São Paulo State University - UNESP, Distrito de Rubiao Junior S/N
