Autor(es):
Silva, Elen Farinelli De Campos [UNESP] ; Baima, Júlio Pinheiro [UNESP] ; De Barros, Jaqueline Ribeiro [UNESP] ; Renosto, Fernanda Lofiego [UNESP] ; De Sibia, Carina De Fatima [UNESP] ; Saad-Hossne, Rogério [UNESP] ; Sassaki, Ligia Yukie [UNESP]
Data: 2019
Identificador Persistente: http://hdl.handle.net/11449/188253
Origem: Oasisbr
Assunto(s): Anti-TNF therapy; Biological therapy; Crohn's disease; Inflammatory bowel disease; Pregnancy; Anti-TNF therapy; Anti-TNF therapy; Biological therapy; Biological therapy; Crohn's disease; Crohn's disease; Inflammatory bowel disease; Inflammatory bowel disease; Pregnancy; Pregnancy
Descrição
Made available in DSpace on 2019-10-06T16:02:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-09-01
Inflammatory bowel disease (IBD) affects young people of reproductive age. Therefore, a broad discussion is needed about the possible disease effects in pregnancy, as well as the risks of fetal exposure to the medications used, especially biological therapy. This study aimed to describe the management of 4 Crohn's disease patients who received anti-TNF therapy during pregnancy and present a literature review. We reported 4 cases composed of young women who became pregnant while receiving anti-TNF agents. The patients presented a satisfactory response to the clinical treatment and the pregnancies progressed without complications. We did not observe maternal or embryonic toxicity, or unfavorable outcomes. The available data point to inflammatory activity as the main risk factor for unfavorable gestational evolution to date, and showed anti-TNF therapy to be safe during pregnancy and breastfeeding. However, the benefits and risks must be discussed with the patient and management decisions should be taken on an individual basis.
Medical School Department of Internal Medicine São Paulo State University (UNESP), Av. Prof. Mario Rubens Guimaraes Montenegro, s/n
Medical School Department of Surgery São Paulo State University (UNESP)
Medical School Department of Internal Medicine São Paulo State University (UNESP), Av. Prof. Mario Rubens Guimaraes Montenegro, s/n
Medical School Department of Surgery São Paulo State University (UNESP)
