Author(s):
Schmidt, Luis Eduardo ; Hadad, Henrique [UNESP] ; De Vasconcelos, Igor Rodrigues ; Colombo, Luara Teixeira [UNESP] ; Da Silva, Rodrigo Capalbo [UNESP] ; Santos, Ana Flavia Piquera [UNESP] ; Cervantes, Lara Cristina Cunha [UNESP] ; Poli, Pier Paolo ; Signorino, Fabrizio ; Maiorana, Carlo ; De Carvalho, Paulo Sérgio Perri ; Souza, Francisley Ávila [UNESP]
Date: 2019
Persistent ID: http://hdl.handle.net/11449/189238
Origin: Oasisbr
Subject(s): Biomaterial; Bone healing; Calcium phosphate cement; Biomaterial; Biomaterial; Bone healing; Bone healing; Calcium phosphate cement; Calcium phosphate cement
Description
Made available in DSpace on 2019-10-06T16:34:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01
(1) Background: The tissue engineering field has been working to find biomaterials that mimic the biological properties of autogenous bone grafts. (2) Aim: To evaluate the osteoconduction potential of injectable calcium phosphate cement implanted in critical defects in rat calvaria. (3) Methods: In the calvarial bone of 36 rats, 7-mm diameter critical size defects were performed. Afterwards, the animals were randomly divided into three groups according to filler material: a blood clot group (BC), blood clot membrane group (BCM), and an injectable β-tricalcium phosphate group (HBS) cement group. After periods of 30 and 60 days, the animals were euthanized, the calvaria was isolated, and submitted to a decalcification process for later blades confection. Qualitative and quantitative analysis of the neoformed bone tissue were conducted, and histometric data were statistically analyzed. (4) Results: Sixty days post-surgery, the percentages of neoformed bone were 10.67 ± 5.57 in group BC, 16.71 ± 5.0 in group BCM, and 55.11 ± 13.20 in group HBS. The bone formation values in group HBS were significantly higher (p < 0.05) than in groups BC and BCM. (5) Conclusions: Based on these results, it can be concluded that injectable calcium phosphate cement is an osteoconductive material that can be used to fill bone cavities.
Implant Dentistry Post-Graduation Program São Leopoldo Mandic School of Dentistry and Research Center
Department of Surgery and Integrated Clinic Araçatuba Dental of School São Paulo State University Júliode Mesquita Filho-UNESP
Implant Center for Edentulism and Jawbone Atrophies Maxillofacial Surgery and Odontostomatology Unit Fondazione IRCSS Cà Granda Maggiore Policlinico Hospital University of Milan
Department of Surgery and Integrated Clinic Araçatuba Dental of School São Paulo State University Júliode Mesquita Filho-UNESP
