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Submitted by LUCAS KENJY BAZAGLIA KURODA (lucas.kuroda@unesp.br) on 2020-04-13T17:11:37Z No. of bitstreams: 1 Defesa_doutorado_Lucas.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Submitted by LUCAS KENJY BAZAGLIA KURODA (lucas.kuroda@unesp.br) on 2020-04-13T17:11:37Z No. of bitstreams: 1 Defesa_doutorado_Lucas.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
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Submitted by LUCAS KENJY BAZAGLIA KURODA (lucas.kuroda@unesp.br) on 2020-04-13T17:11:37Z No. of bitstreams: 1 Defesa_doutorado_Lucas.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Submitted by LUCAS KENJY BAZAGLIA KURODA (lucas.kuroda@unesp.br) on 2020-04-13T17:11:37Z No. of bitstreams: 1 Defesa_doutorado_Lucas.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Submitted by LUCAS KENJY BAZAGLIA KURODA (lucas.kuroda@unesp.br) on 2020-04-13T17:11:37Z No. of bitstreams: 1 Defesa_doutorado_Lucas.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2020-04-15T20:28:46Z (GMT) No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5)
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Made available in DSpace on 2020-04-15T20:28:46Z (GMT). No. of bitstreams: 1 kuroda_lkb_dr_bot.pdf: 5463980 bytes, checksum: 647e7966aa3fc368c5c49ad7ed6cd44e (MD5) Previous issue date: 2020-02-27
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O presente trabalho apresenta a nova modelagem fracionária, que considera propriedades hereditárias e efeitos de memória, no modelo de Gompertz, para descrever a evolução do câncer causado pela infecção do HPV 16. Devido a variabilidade do desenvolvimento do câncer em humanos, utiliza-se o crescimento in vivo do tumor em camundongo transgênico que expressam os oncogenes E6 e E7 tratados com DMBA / TPA (inicializador e promotor do HPV 16) para capturar as características gerais dessa variabilidade. Resultados mostram que a inserção de um novo parâmetro na correção dimensional da modelagem fracionária, descreve, em comparação ao modelo clássico, o progresso do volume tumoral em maior conformidade com os conjuntos de dados reais.
The present work presents the fractional modeling, which considers hereditary properties and memory effects, to describe through the Gompertz model, the evolution of cancer caused by HPV 16 infection. Due to the variability of the development of cancer in humans, we used the in vivo growth of the transgenic mouse tumor expressing DMBA / TPA-treated E6 and E7 oncogenes (HPV 16 initiator and promoter) to capture the general characteristics of this variability. Results show that the insertion of a new parameter in the dimensional correction of fractional modeling describes, compared to the classical model, the progress of tumor volume in greater concorda with the actual data sets.
CAPES: 001
