Author(s):
Portela, Ana Carolina Vellosa ; Silveira, Juliana Grell Fernandes ; Damaceno, Marina Alves ; da Silva, Agnaldo Fernando Baldo ; de Jesus, Raphael Barbetta [UNESP] ; Pilarski, Fabiana [UNESP] ; Gadaj, Anna ; Mooney, Mark H. ; Paschoal, Jonas Augusto Rizzato
Date: 2020
Persistent ID: http://hdl.handle.net/11449/200040
Origin: Oasisbr
Subject(s): albendazole; Aquaculture; feed medication; LC-MS/MS; patinga; tilapia; withdrawal period; albendazole; albendazole; Aquaculture; Aquaculture; feed medication; feed medication; LC-MS/MS; LC-MS/MS; patinga; patinga; tilapia; tilapia; withdrawal period; withdrawal period
Description
Made available in DSpace on 2020-12-12T01:56:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-02
Due to the lack of drugs regulated for aquaculture, we have evaluated the use of albendazole (ABZ)–a potential drug to be regulated for fish–under food safety perspectives assessing the depletion profile of ABZ and its main metabolites (albendazole sulphoxide–ABZSO, albendazole sulphone–ABZSO2 and albendazole amino sulphone–ABZ-2-NH2SO2) in fish fillets (muscle and skin) after single dose oral administration of 10 mg ABZ kg-1 body weight. For the drug administration, a suitable procedure for ABZ incorporation into fish feed was employed, obtaining good homogeneity of ABZ concentration among feed pellets (CV<4.1%) and low drug leaching when medicated feed remained in the water for up to 60 min (<2.7%). After medication, fish were euthanised at 8, 12, 24, 48, 72, 96 and 120 h and fillets collected. Depletion studies in various fish species (patinga and tilapia) were conducted simultaneously, under water temperature at 30.4 ± 0.3 °C and pH 6.8 ± 0.1. The highest concentrations for the sum of residues (ABZ, ABZSO, ABZSO2 and ABZ-2-NH2SO2) in fish fillet were 1210 ng g-1 in patinga and 637 ng g−1 in tilapia. Under the employed rearing conditions, the obtained results did not indicate a requirement for a minimum withdrawal period to be proposed for tilapia considering the maximum residue limit of 100 µg g−1, since the determined residual concentration was
Faculdade de Ciências Farmacêuticas de Ribeirão Preto Departamento de Física e Química Universidade de São Paulo
Centro de Aquicultura da Unesp Universidade Estadual Paulista (Unesp)
Institute for Global Food Security School of Biological Sciences Queen’s University Belfast
Centro de Aquicultura da Unesp Universidade Estadual Paulista (Unesp)
