Author(s):
Mannochio Russo, Helena [UNESP] ; Ferreira Queiroz, Emerson ; Marcourt, Laurence ; Rutz, Adriano ; Allard, Pierre-Marie ; de Almeida, Rafael Felipe ; Marques Carvalho, Nilton ; Wolfender, Jean-Luc ; da Silva Bolzani, Vanderlan [UNESP]
Date: 2020
Persistent ID: http://hdl.handle.net/11449/200179
Origin: Oasisbr
Subject(s): Cattle intoxication; Isolation steroids; Metabolite profile; Monofluoracetate (MFA); Niedenzuella multiglandulosa; UHPLC-PDA-HRMS; Cattle intoxication; Cattle intoxication; Isolation steroids; Isolation steroids; Metabolite profile; Metabolite profile; Monofluoracetate (MFA); Monofluoracetate (MFA); Niedenzuella multiglandulosa; Niedenzuella multiglandulosa; UHPLC-PDA-HRMS; UHPLC-PDA-HRMS
Description
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Niedenzuella multiglandulosa (Malpighiaceae) is a neotropical liana responsible for cattle intoxication outbreaks in Brazil that may lead to abortion and even death of the animals, causing substantial losses in Brazilian trade balance. A phytochemical study of N. multiglandulosa leaves was performed in order to obtain chemical information about secondary metabolites of this poorly studied species. The methanolic extract was purified by medium pressure liquid chromatography (MPLC) combined with semi preparative HPLC-PDA leading to the isolation of 16 compounds, including a new steroid named 5-hydroxypodecdysone B (13). The structure of the isolated compounds was determined by classical spectroscopic methods such as NMR and HRMS. Complementary 19F NMR and UPLC-HRMS analysis did not detect the presence of monofluoracetate (MFA), a toxic compound previously described from this species.
Nucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)
School of Pharmaceutical Sciences University of Geneva University of Lausanne, 1, Rue Michel-Servet
Departament of Botany Institute of Biological Sciences Federal University of Minas Gerais (UFMG), Belo Horizonte
Faculty of Veterinary Medicine and Zootechnics (FAMEZ) Feredal University of Mato Grosso do Sul (UFMS), Campo Grande
Nucleus of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry São Paulo State University (UNESP)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung: 316030_164095
