Autor(es):
Castro, Kenia Mendes Rodrigues ; de Paiva Carvalho, Rodrigo Leal [UNESP] ; Junior, Geraldo Marco Rosa ; Tavares, Beatriz Antoniassi ; Simionato, Luis Henrique ; Bortoluci, Carlos Henrique Fachin ; Soto, Claudio Alberto Tellez ; Ferraresi, Cleber
Data: 2020
Identificador Persistente: http://hdl.handle.net/11449/200261
Origem: Oasisbr
Assunto(s): Blood glucose; Diabetes mellitus; Glycogen; LED therapy; Low-level laser therapy; Blood glucose; Blood glucose; Diabetes mellitus; Diabetes mellitus; Glycogen; Glycogen; LED therapy; LED therapy; Low-level laser therapy; Low-level laser therapy
Descrição
Made available in DSpace on 2020-12-12T02:01:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-06-01
Photobiomodulation therapy (PBMT) has many effects on the energy metabolism of musculoskeletal tissue, such as increased glycogen and adenosine triphosphate synthesis. In addition, these effects may be due to a systemic blood glucose control. Twenty-four Wistar rats were randomly and equally allocated into four groups: sham, PBMT 10 J/cm2, PBMT 30 J/cm2 and PBMT 60 J/cm2. The animals were fasting for 6 h for blood glucose evaluations during pre-irradiation period, 1 h, 3 h and 6 h after PBMT. Muscle glycogen synthesis was measured 24 h after PBMT. This PBMT used a cluster of 69 LEDs (light-emitting diodes) with 35 red (630 ± 10 nm) and 34 infrared (850 ± 20 nm); 114 mW/cm2 for 90s (10 J/cm2), 270 s (30 J/cm2), 540 s (60 J/cm2) applied on large muscle areas (back and hind legs) of the animals. The 10 J/cm2 group showed lower blood glucose levels and glucose variability over 6 h (5.92 mg/dL) compared to the sham (13.03 mg/dL), 30 J/cm2 (7.77 mg/dL) and 60 J/cm2 (9.07 mg/dL) groups. The PBMT groups had the greatest increase in muscle glycogen (10 J/cm2 > 60 J/cm2 > 30 J/cm2 > sham), characterizing a triphasic dose-response of PBMT. There was a strong negative correlation between blood glucose variability over 6 h and muscle glycogen concentration for 10 J/cm2 group (r = −0.94; p < .001) followed by 30 J/cm2 group (r = −0.84; p < .001) and 60 J/cm2 group(r = −0.73; p < .006). These results suggest that PBMT can play a very important role in the control of blood glucose levels, and its possible mechanism of action is the induction of greater muscle glycogen synthesis independently of physical exercise.
Post-Graduation Program in Biomedical Engineering Universidade Brasil
Laboratory of Physiology and Human Performance São Paulo State University – UNESP, Bauru
Universidade do Sagrado Coração (USC) Bauru
Laboratory of Physiology and Human Performance São Paulo State University – UNESP, Bauru
