Author(s):
de Souza, Sérgio Luiz Borges [UNESP] ; Mota, Gustavo Augusto Ferreira [UNESP] ; Gregolin, Cristina Schmitt ; do Nascimento, Milena ; Luvizotto, Renata Azevedo Melo ; Bazan, Silmeia Garcia Zanati [UNESP] ; Sugizaki, Mário Mateus ; Barbisan, Luis Fernando [UNESP] ; Cicogna, Antonio Carlos [UNESP] ; do Nascimento, André Ferreira
Date: 2020
Persistent ID: http://hdl.handle.net/11449/200270
Origin: Oasisbr
Subject(s): Cardiac dysfunction; Cirrhotic cardiomyopathy; Exercise training; Liver cirrhosis; Thioacetamide; Cardiac dysfunction; Cardiac dysfunction; Cirrhotic cardiomyopathy; Cirrhotic cardiomyopathy; Exercise training; Exercise training; Liver cirrhosis; Liver cirrhosis; Thioacetamide; Thioacetamide
Description
Made available in DSpace on 2020-12-12T02:02:09Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01
Cirrhotic cardiomyopathy is a condition where liver cirrhosis is associated with cardiac dysfunction. Triggers and blockers of cirrhotic cardiomyopathy are poorly understood, which might compromise the prognosis of chronic liver disease patients. We tested whether exercise training would reduce liver damage induced by thioacetamide and prevent liver cirrhosis-associated cardiomyopathy. Wistar rats were divided into three groups: control, thioacetamide (TAA), or TAA plus exercise. Thioacetamide increased liver weight and serum alanine aminotransferase and aspartate aminotransferase levels. Also, TAA treatment was involved with hepatic nodule formation, fibrotic septa, inflammatory infiltration, and hepatocyte necrosis. The exercise group presented with a reduction in liver injury status. We found that liver injury was associated with disordered cardiac hypertrophy as well as diastolic and systolic dysfunction. Exercise training attenuated cirrhosis-associated cardiac remodeling and diastolic dysfunction and prevented systolic impairment. These results provided insights that exercise training can mitigate cirrhotic cardiomyopathy phenotype. [Figure not available: see fulltext.].
Department of Internal Medicine Botucatu School of Medicine São Paulo State University (UNESP), Botucatu
Institute of Health Sciences Federal University of Mato Grosso (UFMT), Avenida Alexandre Ferronato, n°1200, Setor Industrial
Department of Morphology Institute of Biosciences Sao Paulo State University (UNESP)
Department of Internal Medicine Botucatu School of Medicine São Paulo State University (UNESP), Botucatu
Department of Morphology Institute of Biosciences Sao Paulo State University (UNESP)
