Author(s): Nicolosi, Bianca F. [UNESP] ; Souza, Renato T. ; Mayrink, Jussara ; Feitosa, Francisco E. ; Rocha Filho, Edilberto A. ; Leite, Débora F. ; Vettorazzi, Janete ; Sousa, Maria H. ; Costa, Maria L. ; Baker, Philip N. ; Kenny, Louise C. ; Cecatti, Jose G. ; Calderon, Iracema M. [UNESP]
Date: 2020
Persistent ID: http://hdl.handle.net/11449/200402
Origin: Oasisbr
Made available in DSpace on 2020-12-12T02:05:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-05-01
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Bill and Melinda Gates Foundation
Objective To assess the incidence and risk factors for hyperglycemia in pregnancy in a cohort of Brazilian nulliparous pregnant women. Materials and methods This is a secondary analysis of a multicenter cohort study that enrolled 1,008 nulliparous pregnant women at 19–21 weeks. Exclusion criteria included chronic exposure to corticosteroids and previous diabetes. Bivariate and multivariate analyses by Poisson regression were used to identify associated factors. Results The incidence of hyperglycemia in pregnancy was 14.9% (150/1,008), and 94.7% of these cases were gestational diabetes mellitus (142/150). Significant associated factors included a family history of diabetes mellitus, maternal overweight or obesity at enrollment, and previous maternal conditions (polycystic ovarian syndrome, thyroid dysfunctions and hypertensive disorders). A BMI ≥ 26.3Kg/m2 (RRadj 1.87 [1.66–2.10]) and a family history of diabetes mellitus (RRadj 1.71 [1.37–2.15]) at enrollment were independent risk factors for HIP. Conclusions A family history of diabetes mellitus and overweight or obesity (until 19–21 weeks of gestation) may be used as selective markers for HIP in Brazilian nulliparous women. Given the scarcity of results in nulliparous women, our findings may contribute to determine the optimal diagnostic approach in populations of similar socioeconomic characteristics.
Department of Obstetrics and Gynecology Botucatu Medical School Unesp
Department of Obstetrics and Gynecology University of Campinas (UNICAMP) School of Medical Sciences
MEAC–Maternity School of the Federal University of Ceará
Department of Maternal and Child Health Maternity of Clinic Hospital Federal University of Pernambuco
Department of Obstetrics and Gynecology Maternity of the Clinic Hospital Federal University of RS
Statistics Unit Jundiai School of Medicine Jundiaí
College of Life Sciences University of Leicester
Faculty of Health and Life Sciences Department of Women’s and Children’s Health Institute of Translational Medicine University of Liverpool
Department of Obstetrics and Gynecology Botucatu Medical School Unesp
CNPq: 401636/2013-5
Bill and Melinda Gates Foundation: OPP1107597
