Author(s):
Silva, Robson R. ; Raymundo-Pereira, Paulo A. ; Campos, Anderson M. ; Wilson, Deivy ; Otoni, Caio G. ; Barud, Hernane S. ; Costa, Carlos A.R. ; Domeneguetti, Rafael R. [UNESP] ; Balogh, Debora T. ; Ribeiro, Sidney J.L. [UNESP] ; Oliveira Jr., Osvaldo N.
Date: 2020
Persistent ID: http://hdl.handle.net/11449/200421
Origin: Oasisbr
Subject(s): Bacterial cellulose; Biosensor; Estradiol; Heavy metals; Uric acid; Wearable electronics; Bacterial cellulose; Bacterial cellulose; Biosensor; Biosensor; Estradiol; Estradiol; Heavy metals; Heavy metals; Uric acid; Uric acid; Wearable electronics; Wearable electronics
Description
Made available in DSpace on 2020-12-12T02:06:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-01
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
The pursuit of biocompatible, breathable and skin-conformable wearable sensors has predominantly focused on synthetic stretchable hydrophobic polymers. Microbial nanocellulose (MNC) is an exceptional skin-substitute natural polymer routinely used for wound dressing and offers unprecedented potential as substrate for wearable sensors. A versatile strategy for engineering wearable sensing platforms is reported, with sensing units made of screen-printed carbon electrodes (SPCEs) on MNC. As-prepared SPCEs were used to detect the toxic metals cadmium (Cd2+) and lead (Pb2+) with limits of detection of 1.01 and 0.43 μM, respectively, which are sufficient to detect these metal ions in human sweat and urine. SPCEs functionalized through anodic pre-treatments were used for detecting uric acid and 17β-estradiol in artificial sweat, with detection limits of 1.8 μM and 0.58 μM, respectively. The electrochemical treatment created oxygen groups on the carbon surfaces, thus improving wettability and hydrophilicity. MNC was herein exploited as an adhesive-free, yet highly skin-adherent platform for wearable sensing devices that also benefit from the semi-permeable, non-allergenic, and renewable features that make MNC unique within the pool of materials that have been used for such a purpose. Our findings have clear implications for the developments on greener and more biocompatible but still efficient substrates and may pave the route for combining immunosensing devices with drug delivery therapies.
São Carlos Institute of Physics University of São Paulo (USP)
São Carlos Institute of Chemistry University of São Paulo (USP)
Institute of Chemistry University of Campinas (UNICAMP), P.O. Box 6154
Biopolymers and Biomaterials Laboratory (BIOPOLMAT) University Center of Araraquara (UNIARA)
Brazilian Nanotechnology National Laboratory (LNNano) Brazilian Center for Research in Energy and Materials (CNPEM)
São Paulo State University (UNESP) Department of General and Inorganic Chemistry Rua Professor Francisco Degni, 55, Araraquara14800-060
São Paulo State University (UNESP) Department of General and Inorganic Chemistry Rua Professor Francisco Degni, 55, Araraquara14800-060
FAPESP: 2013/14262–7
FAPESP: 2015/01770–0
FAPESP: 2016/01919–6
FAPESP: 2016/06612–6
CNPq: 423952/2018-8
