Author(s):
Carminatti, Marina [UNESP] ; Benetti, Francine [UNESP] ; Siqueira, Renato Luiz ; Zanotto, Edgar Dutra ; Briso, André Luiz Fraga [UNESP] ; Chaves-Neto, Antônio Hernandes [UNESP] ; Cintra, Luciano Tavares Angelo [UNESP]
Date: 2020
Persistent ID: http://hdl.handle.net/11449/200594
Origin: Oasisbr
Subject(s): Bioactive glass; Dental pulp; Hydrogen peroxide; Tooth bleaching; Tooth remineralization; Bioactive glass; Bioactive glass; Dental pulp; Dental pulp; Hydrogen peroxide; Hydrogen peroxide; Tooth bleaching; Tooth bleaching; Tooth remineralization; Tooth remineralization
Description
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Objectives: This study evaluated if the use of a bioactive glass-ceramicbased gel, named Biosilicate (BS), before, after or mixed with bleaching gel, could influence the inflammation of the dental pulp tissue of rats’ molars undergoing dental bleaching with hydrogen peroxide (H2O2). Methodology: The upper molars of Wistar rats (Rattus norvegicus, albinus) were divided into Ble: bleached (35% H2O2, 30-min); Ble-BS: bleached and followed by BS-based gel application (20 min); BS-Ble: BS-based gel application and then bleaching; BS/7d-Ble: BS-based gel applications for 7 days and then bleaching; Ble+BS: blend of H2O2 with BS-based gel (1:1, 30-min); and control: placebo gel. After 2 and 30 days (n=10), the rats were euthanized for histological evaluation. The Kruskal-Wallis and Dunn statistical tests were performed (P<0.05). Results: At 2 days, the Ble and Ble-BS groups had significant alterations in the pulp tissue, with an area of necrosis. The groups with the application of BS-based gel before H2O2 had moderate inflammation and partial disorganization in the occlusal third of the coronary pulp and were significantly different from the Ble in the middle and cervical thirds (P<0.05). The most favorable results were observed in the Ble+BS, which was similar to the control in all thirds of the coronary pulp (P>0.05). At 30 days, the pulp tissue was organized and the bleached groups presented tertiary dentin deposition. The Ble group had the highest deposition of tertiary dentin, followed by the Ble-BS, and both were different from control (P<0.05). Conclusion: A single BS-based gel application beforehand or BS-based gel blended with a bleaching gel minimize the pulp damage induced by dental bleaching.
Universidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Odontologia Preventiva e Restauradora
Universidade Federal de Minas Gerais (UFMG) Faculdade de Odontologia Departamento de Odontologia Restauradora
Universidade Federal de São Carlos (UFSCar) Departamento de Engenharia de Materiais Laboratório de Materiais Vitreos
Universidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas
Universidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Odontologia Preventiva e Restauradora
Universidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas
FAPESP: 2013/07793-6
FAPESP: 2015/22996-6
CNPq: 311650/2018-0
