Author(s):
de Farias, Aline Leite [UNESP] ; Meneguin, Andréia Bagliotti [UNESP] ; da Silva Barud, Hernane ; Brighenti, Fernanda Lourenção [UNESP]
Date: 2020
Persistent ID: http://hdl.handle.net/11449/200950
Origin: Oasisbr
Subject(s): Alginate; Controlled drug delivery; Dental plaque; Gellan gum; Morin hydrate; Polysaccharides; Alginate; Alginate; Controlled drug delivery; Controlled drug delivery; Dental plaque; Dental plaque; Gellan gum; Gellan gum; Morin hydrate; Morin hydrate; Polysaccharides; Polysaccharides
Description
Made available in DSpace on 2020-12-12T02:20:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-11-01
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
The use of controlled drug delivery systems represents an alternative and promising strategy for the use of antimicrobials in the oral cavity. Microparticles, films and oral tablets based on alginate and gellan gum were developed also as a strategy to overcome the low aqueous solubility of morin. The systems were characterized in terms of morphological characteristics, mucoadhesion and in vitro drug release. Antibiofilm activity was analyzed for acidogenicity, microbial viability and the composition of the extracellular matrix of single-species biofilms. Scanning Electron Microscopy demonstrated that the microparticles were spherical, rough and compact. The film and the tablet presented smooth and continuous surface and in the inner of the tablet was porous. These systems were more mucoadhesive compared to the microparticles. The in vitro morin release profiles in artificial saliva demonstrated that the microparticles controlled the release better (39.6%), followed by the film (41.1%) and the tablet (91.4%) after 20 h of testing. The morin released from the systems reduced the acidogenicity, microbial viability, concentration of insoluble extracellular polysaccharides and dry weight of biofilms, when compared to the control group. The findings of this study showed that the morin has antibiofilm activity against cariogenic microorganisms.
Department of Morphology Pediatric Dentistry and Orthodontics School of Dentistry São Paulo State University - UNESP
Department of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University-UNESP
Biopolymers and Biomaterials Laboratory (BioPolMat) University of Araraquara - UNIARA
Department of Morphology Pediatric Dentistry and Orthodontics School of Dentistry São Paulo State University - UNESP
Department of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University-UNESP
FAPESP: 2013/07276-1
FAPESP: 2013/12326-8
FAPESP: 2018/25512-8
CNPq: 304383/20163
CNPq: 407822/2018-6
FAPESP: CEPID - 13/07276-1
