Author(s):
Sant’ Anna, B. G. ; Musolino, N. R.C. ; Gadelha, M. R. ; Marques, C. ; Castro, M. ; Elias, P. C.L. ; Vilar, L. ; Lyra, R. ; Martins, M. R.A. ; Quidute, A. R.P. ; Abucham, J. ; Nazato, D. ; Garmes, H. M. ; Fontana, M. L.C. ; Boguszewski, C. L. ; Bueno, C. B. ; Czepielewski, M. A. ; Portes, E. S. ; Nunes-Nogueira, V. S. [UNESP] ; Ribeiro-Oliveira, A. ; Francisco, R. P.V. ; Bronstein, M. D. ; Glezer, A.
Date: 2020
Persistent ID: http://hdl.handle.net/11449/201082
Origin: Oasisbr
Subject(s): Cabergoline; Dopamine agonist; Malformation; Miscarriage; Pregnancy; Prolactinoma; Cabergoline; Cabergoline; Dopamine agonist; Dopamine agonist; Malformation; Malformation; Miscarriage; Miscarriage; Pregnancy; Pregnancy; Prolactinoma; Prolactinoma
Description
Made available in DSpace on 2020-12-12T02:23:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01
Objective: To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods: The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study, Results: We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Conclusions: Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.
Division of Endocrinology and Metabolism Hospital das Clinicas Neuroendocrine Unit University of Sao Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, no 155, 8° andar, bloco 3 (Endocrinologia)
Division of Neurosurgery Institute of Psychiatry University of Sao Paulo Medical School
Federal University of Rio de Janeiro
University of Sao Paulo Medical School of Ribeirao Preto
Federal University of Pernambuco
Federal University of Ceara
Escola Paulista de Medicina Universidade Federal de São Paulo
State University of Campinas
Endocrine Division (SEMPR) Department of Internal Medicine Federal University of Parana
Irmandade da Santa Casa de Misericórdia de São Paulo
Division of Endocrinology Hospital de Clinicas de Porto Alegre (UFRGS)
Institute of Medical Assistance to the State Public Hospital
São Paulo State University (UNESP) Medical School
Federal University of Minas Gerais
Disciplina de Obstetrícia Departamento de Obstetrícia e Ginecologia Faculdade de Medicina (FMUSP) Universidade de São Paulo
São Paulo State University (UNESP) Medical School
