Autor(es): Guerra, Luiz Henrique Alves [UNESP] ; Tamarindo, Guilherme Henrique ; de Campos, Silvana Gisele Pegorin ; Taboga, Sebastião Roberto [UNESP] ; Vilamaior, Patricia Simone Leite [UNESP]
Data: 2020
Identificador Persistente: http://hdl.handle.net/11449/201206
Origem: Oasisbr
Assunto(s): Corn oil; Gerbil; Mineral oil; Prostate; Vehicle; Corn oil; Corn oil; Gerbil; Gerbil; Mineral oil; Mineral oil; Prostate; Prostate; Vehicle; Vehicle
Made available in DSpace on 2020-12-12T02:26:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01
Vegetable oils are frequently used as a vehicle in the administration of lipophilic drugs in animal tests. However, the composition of these oils may interfere with the results. One alternative to reduce this potential bias is the use of mineral oil, which is not supposed to interfere in the physiology of experimental models, since this oil is considered to be innocous. The present study shows for the first time the effects of the oral administration of corn and mineral on the prostate, demonstrating their interference in homeostasis and revealing their potential to act as endocrine disruptors. Mineral oil treatment increased the expression of AR and ERα and serum estradiol concentrations, while corn oil increased the expression of positive cells for both types of estrogen receptors. The variation in the expression of these hormone receptors resulted in morphological changes in the prostate.
Department of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University – UNESP
Department of Functional and Structural Biology Institute of Biology University of Campinas – UNICAMP
Federal University of São João Del Rei Central-West Campus
Department of Biology Institute of Biosciences Humanities and Exact Sciences São Paulo State University – UNESP
