Autor(es):
Siqueira, Idalia Aparecida Waltrick Brito ; Amaral, Suelen Simões [UNESP] ; de Moura, Nayara Koba ; Machado, João Paulo Barros ; Backes, Eduardo Henrique ; Passador, Fábio Roberto ; Camargo, Samira Esteves Afonso ; de Vasconcellos, Luana Marotta Reis [UNESP] ; Trichês, Eliandra Sousa
Data: 2020
Identificador Persistente: http://hdl.handle.net/11449/201329
Origem: Oasisbr
Assunto(s): Bioactivity; Calcium silicate fibers; PLA; Porous polymeric membranes; SBF; Bioactivity; Bioactivity; Calcium silicate fibers; Calcium silicate fibers; PLA; PLA; Porous polymeric membranes; Porous polymeric membranes; SBF; SBF
Descrição
Made available in DSpace on 2020-12-12T02:29:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-01
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
A new approach in dentistry is based on the development of resorbable polymeric membranes for guided bone regeneration. The porous membrane surface promotes better cell adhesion and proliferation. Poly(lactic acid) (PLA) is one of most widely used polymers for several biological applications, with the advantage of presenting hydrolysis degradation and bioresorption of its products. In this work, PLA porous polymeric membranes containing calcium silicate (CaSiO3) fibers were prepared by controlled humidity technique. The porous membranes were characterized by scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, bioactivity in simulated body fluid and biological studies in vitro. The incorporation of the CaSiO3 fibers into the polymeric matrix increased the pore size (1.5–34.9 µm). In the bioactivity assay, PLA/CASiO3 membranes induced the formation of a hydroxyapatite layer on the porous membrane surface. Also, in vitro biologic assays showed that the porous membranes provided suitable environment for cell attachment and proliferation.
Federal University of São Paulo (UNIFESP), 330 Talim St
Institute of Science and Technology UNESP – Univ Estadual Paulista State University of São Paulo (UNESP), 777 Av. Eng. Francisco José Longo
National Institute for Space Research (INPE), 1758 dos Astronautas Avenue
Federal University of São Carlos, 235 km Washington Luís
Department of Restorative Dental Sciences College of Dentistry University of Florida (UFL)
Institute of Science and Technology UNESP – Univ Estadual Paulista State University of São Paulo (UNESP), 777 Av. Eng. Francisco José Longo
FAPESP: 2012/ 07897-3
FAPESP: 2015/24659-7
