Author(s):
Reis, Juliana Santana [UNESP] ; Corrêa, Marcos Antonio [UNESP] ; Ribeiro, Clovis Augusto [UNESP] ; Dos Santos, Jean Leandro [UNESP]
Date: 2020
Persistent ID: http://hdl.handle.net/11449/201333
Origin: Oasisbr
Subject(s): 1,3,5-triazine; Antioxidant; EHT; Molecular optimization; Photoprotection; Skin cancer; Sunscreens; UV filters; UV radiation; 1,3,5-triazine; 1,3,5-triazine; Antioxidant; Antioxidant; EHT; EHT; Molecular optimization; Molecular optimization; Photoprotection; Photoprotection; Skin cancer; Skin cancer; Sunscreens; Sunscreens; UV filters; UV filters; UV radiation; UV radiation
Description
Made available in DSpace on 2020-12-12T02:29:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-15
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Universidade Estadual Paulista
The incidence of skin cancers such as non-melanoma skin cancer and malignant melanoma has increased in the last few years mainly because of chronic exposure to ultraviolet (UV) radiation. Sunscreens protect the skin against harmful UV radiations; however, some limitations of these products justify the discovery of new UV filters. Novel 1,3,5-triazine derivatives (12a-h) obtained by the optimization of prototype resveratrol were synthesized and characterized. All compounds exhibited sun protection factor (SPF) and UVA protection factor (UVAPF) in the range of 3–17 and 3–13, respectively. These values were superior to resveratrol and the UV filter ethylhexyl triazone (EHT) currently available on the market. In addition, all compounds demonstrated in vitro antioxidant activity and thermal stability with the decomposition at temperatures above 236 °C. In conclusion, the novel 1,3,5-triazine derivatives have emerged as new UV filters with antioxidant effect useful to prevent skin cancer.
São Paulo State University (UNESP) School of Pharmaceutical Science
São Paulo State University (UNESP) Institute of Chemistry
São Paulo State University (UNESP) School of Pharmaceutical Science
São Paulo State University (UNESP) Institute of Chemistry
FAPESP: 18/11079-0
CNPq: 430172/2018-4
