Author(s):
Hilario, Felipe [UNESP] ; Polinário, Giulia [UNESP] ; de Amorim, Marcelo Rodrigues [UNESP] ; de Sousa Batista, Victor [UNESP] ; do Nascimento Júnior, Nailton Monteiro [UNESP] ; Araújo, Angela Regina [UNESP] ; Bauab, Taís Maria [UNESP] ; dos Santos, Lourdes Campaner [UNESP]
Date: 2020
Persistent ID: http://hdl.handle.net/11449/201444
Origin: Oasisbr
Subject(s): Antibacterial activity; Curvularia lunata; Curvulinic acid; Paepalanthus chiquitensis; Spirocyclic lactams; Antibacterial activity; Antibacterial activity; Curvularia lunata; Curvularia lunata; Curvulinic acid; Curvulinic acid; Paepalanthus chiquitensis; Paepalanthus chiquitensis; Spirocyclic lactams; Spirocyclic lactams
Description
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Curvularia lunata, isolated from the capitula of Paepalanthus chiquitensis (Eriocaulaceae), was cultured in potato dextrose broth (PDB) medium. The ethyl acetate extract yielded two new spirocyclic γ-lactams (3 and 4), and five known compounds, namely: triticones E (1) and F (2), 5-O-methylcurvulinic acid (5), curvulinic acid (6) and curvulin (7). Their structures were elucidated by spectroscopic analysis and by the comparison with literature data. Besides, a computational study was used to elucidate the absolute configuration of the C − 3′ in the compounds (3) and (4). The extract and the compounds (1 and 2), (6) and (7) were assayed against gram-positive and gram-negative bacteria and fluconazole-resistant yeast. The triticones (1) and (2) showed good antibacterial activity for Escherichia coli, with a minimum inhibitory concentration of 62.5 μg/mL.
São Paulo State University (UNESP) School of Pharmaceutical Sciences, Road Araraquara-Jaú km1
São Paulo State University (UNESP) Institute of Chemistry, Av. Prof. Francisco Degni n.55
São Paulo State University (UNESP) School of Pharmaceutical Sciences, Road Araraquara-Jaú km1
São Paulo State University (UNESP) Institute of Chemistry, Av. Prof. Francisco Degni n.55
FAPESP: 2016/05480-6
