Author(s):
Alegre, Patricia [UNESP] ; Mathias, Livia [UNESP] ; Lourenço, Maria Angelica [UNESP] ; Dos Santos, Priscila Portugal [UNESP] ; Gonçalves, Andrea [UNESP] ; Fernandes, Ana Angélica [UNESP] ; Gaiolla, Paula Schmidt Azevedo [UNESP] ; Minicucci, Marcos Ferreira [UNESP] ; Zornoff, Leonardo [UNESP] ; Paiva, Sergio Alberto Rupp [UNESP] ; Polegato, Bertha Furlan [UNESP]
Date: 2020
Persistent ID: http://hdl.handle.net/11449/201552
Origin: Oasisbr
Subject(s): Chemical Reactions; Energy Metabolism; Euterpe Olerácea; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidative Stress; Rats; Chemical Reactions; Chemical Reactions; Energy Metabolism; Energy Metabolism; Euterpe Olerácea; Euterpe Olerácea; Myocardial Ischemia; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Reperfusion Injury; Oxidative Stress; Oxidative Stress; Rats; Rats
Description
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Background: Euterpe oleracea Mart. (açaí) is a fruit with high antioxidant capacity and could be an adjuvant strategy to attenuate ischemia-reperfusion injury. Objective: To evaluate the influence of açaí in global ischemia-reperfusion model in rats. Methods: Wistar rats were assigned to 2 groups: Control (C: receiving standard chow; n = 9) and Açaí (A: receiving standard chow supplemented with 5% açaí; n = 10). After six weeks, the animals were subjected to the global ischemia-reperfusion protocol and an isolated heart study to evaluate left ventricular function. Level of significance adopted: 5%. Results: There was no difference between the groups in initial body weight, final body weight and daily feed intake. Group A presented lower lipid hydroperoxide myocardial concentration and higher catalase activity, superoxide dismutase and glutathione peroxidase than group C. We also observed increased myocardial activity of β-hydroxyacyl coenzyme-A dehydrogenase, pyruvate dehydrogenase, citrate synthase, complex I, complex II and ATP synthase in the A group as well as lower activity of the lactate dehydrogenase and phosphofructokinase enzymes. The systolic function was similar between the groups, and the A group presented poorer diastolic function than the C group. We did not observe any difference between the groups in relation to myocardial infarction area, total and phosphorylated NF-κB, total and acetylated FOXO1, SIRT1 and Nrf-2 protein expression. Conclusion: despite improving energy metabolism and attenuating oxidative stress, açai supplementation did not decrease the infarcted area or improve left ventricular function in the global ischemia-reperfusion model. (Arq Bras Cardiol. 2020; 114(1):78-86).
Universidade Estadual Paulista Júlio de Mesquita Filho-UNESP
Universidade Estadual Paulista Júlio de Mesquita Filho-UNESP
