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Chromoblastomycosis is a cutaneous fungal infection caused by dematiaceous fungi that belong to the order Chaetothyriales and family Herpotrichiellaceae. This infection is prevalent in tropical and subtropical areas and has been designated as a neglected tropical disease according to the WHO. Chromoblastomycosis infection is difficult to treat, and there are limited therapeutic options, making urgent the characterization of new medicines or approaches to treat such infection. In the present case report, two patients with extensive chromoblastomycosis lesions were treated with the combination of itraconazole, acitretin, and imiquimod. In the fourth month of treatment, both patients showed improvement of verrucous plates, suggesting that acitretin combined with drugs already used in chromoblastomycosis therapy can decrease the time of treatment, improving patient’s quality of life.

Dermatology Department Clinics Hospital Medical School University of São Paulo

Laboratory of Pathology of Infectious Diseases Medical School University of São Paulo

ABC School of Medicine Fundação Universitária do ABC (FUABC)

Institute of Biosciences São Paulo State University (UNESP)

Institute for Advanced Studies of Ocean São Paulo State University (UNESP)

Institute of Biosciences São Paulo State University (UNESP)

Institute for Advanced Studies of Ocean São Paulo State University (UNESP)