Document details

A hierarchical cascade of protein post- translational modifications governs the assembly of the Bacillus subtilis inner coat hub SafA

Author(s): Amara, Khira

Date: 2026

Persistent ID: http://hdl.handle.net/10362/204238

Origin: Repositório Institucional da UNL

Subject(s): Spore resilience; SafA protein; protein interactions


Description

"Bacterial endospores represent a paradigm of microbial resistance and persistence; they withstand extreme environments and remain viable over extended timescales, exemplifying one of the most remarkable survival strategies in nature. Spore resilience is, in part, attributed to the coat, a multilayered protein structure. In Bacillus subtilis, the coat is composed of more than 80 proteins organized into an inner and outer layers, and outermost crust. Its morphogenesis is governed by sigma factor-regulated gene expression and a coordinated interplay of morphogenetic proteins and enzymes. This regulation directs the ordered deposition of proteins into distinct layers around the developing spore and their subsequent stabilization.(...)".

Document Type Doctoral thesis
Language English
Contributor(s) RUN; Henriques, Adriano
CC Licence
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