Author(s): Konstantyner,Thais Claudia Roma de Oliveira ; Silva,Aline Medeiros da ; Tanaka,Luana Fiengo ; Marques,Heloísa Helena de Sousa ; Latorre,Maria do Rosário Dias de Oliveira
Date: 2013
Origin: Oasisbr
Subject(s): Oral Candidiasis; HIV; Acquired Immunodeficiency Syndrome; Child; Survival Analysis; Oral Candidiasis; Oral Candidiasis; HIV; HIV; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndrome; Child; Child; Survival Analysis; Survival Analysis
In clinical practice, recurrence of thrush is common in children living with HIV/AIDS. The aim of this study was to determine the factors associated with time spent free of oral candidiasis using survival analysis for recurrent events. A retrospective cohort study was carried out with 287 children treated between 1985 and 2009 at a reference center in the city of São Paulo, Brazil. The Prentice, Williams and Peterson model for recurrent events was used for the investigation of factors associated with the time free of oral candidiasis. The following factors were associated with the time patients were free of oral candidiasis: moderate immunodepression (HR = 2.5; p = 0.005), severe immunodepression (HR = 3.5; p < 0.001), anemia (HR = 3.3; p < 0.001), malnutrition (HR = 2.6; p = 0.004), hospitalization (HR = 2.2; p < 0.001), monotherapy (HR = 0.5; p = 0.006), dual therapy (HR = 0.3; p < 0.001) and triple therapy/highly active antiretroviral therapy (HR = 0.1; p < 0.001). The method analyzed in the present study proved useful for the investigation of recurrent events in patients living with HIV/AIDS.
