Autor(es):
Moreira, André ; Rodrigues, Ana Carolina Félix ; Reis, Ana Catarina Almeida ; Costa, Elisabete C. ; Ferreira, Paula ; Correia, Ilídio Joaquim Sobreira
Data: 2018
Identificador Persistente: http://hdl.handle.net/10400.6/6609
Origem: uBibliorum
Projeto/bolsa:
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID/Multi/00709/2013/PT;
info:eu-repo/grantAgreement/FCT/POR_CENTROBolsa de Doutoramento/SFRH/BD/109482/2015/PT;
info:eu-repo/grantAgreement/FCT/Bolsa de Doutoramento/SFRH/BD/103507/2014/PT;
Assunto(s): Cancer; Combinatorial therapy; Drug-delivery; Gold-core silica shell nanorods; Photothermal therapy; Cancer; Cancer; Combinatorial therapy; Combinatorial therapy; Drug-delivery; Drug-delivery; Gold-core silica shell nanorods; Gold-core silica shell nanorods; Photothermal therapy; Photothermal therapy
Descrição
Aim: Develop a new poly-2-ethyl-2-oxazoline (PEOZ)-based coating for doxorubicin-loaded gold-core mesoporous silica shell (AuMSS) nanorods application in cancer chemo-photothermal therapy. Methods: PEOZ functionalized AuMSS nanorods were obtained through the chemical grafting on AuMSS of a PEOZ silane derivative. Results: The PEOZ chemical grafting on the surface of AuMSS nanorods allowed the neutralization of nanodevices’ surface charge, from -30 to -15 mV, which improved nanoparticles’ biocompatibility, namely by decreasing the blood hemolysis to negligible levels. In vitro antitumoral studies revealed that the combined treatment mediated by the PEOZ-coated AuMSS nanorods result in a synergistic effect, allowing the complete eradication of cervical cancer cells. Conclusion: The application of the PEOZ coating improves the AuMSS nanorods performance as a multifunctional combinatorial therapy for cervical cancer.
