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Metabolomic Signatures of Biotrauma Associated with Mortality in ICU Patients R...
Fonseca, Tiago A.H.; Von Rekowski, Cristiana P.; Araújo, Rúben; Justino, Gonçalo C.; Oliveira, M. Conceição; Bento, Luís; Calado, Cecília R.C.Background: Biotrauma from invasive mechanical ventilation (IMV) and extracorporeal membrane oxygenation (ECMO) drives systemic inflammation, metabolic dysregulation, and organ dysfunction in critically ill patients. Therefore, this study aimed to identify clinical and metabolomic features associated with ICU mortality in patients receiving IMV or ECMO, as these remain incompletely characterized. Methods: The r...
Effects of a monetary union on a small peripheral country: stabilization and co...
Castro, Henrique Moreira da Silva de OliveiraThe first decade of the 21st century introduced the euro in Portugal. This step towards European integration implied that Portuguese economic authorities lose monetary independence. We investigate the impact of that loss in Portuguese competitiveness through the construction of competitiveness indicators, and on current account dynamics trough a decomposition of the current account. Despite the continuous loss ...
Eco-phenotypic diversity in European Middle Pleistocene Hippopotamus populations
Martino, Roberta; Fidalgo, Darío; Rivals, Florent; Pandolfi, LucaNow limited to Africa, hippopotamids once represented a common element of the European megafauna. However, the ecological and phenotypic diversity of European hippopotamuses is still not fully understood. Within this fragmented framework, a mandible discovered in lacustrine deposits near Ortona (Abruzzo, Italy) provides an opportunity to better understand the morphological and morphometric diversity of European...
Clinical predictors of response to methotrexate in patients with rheumatoid art...
Rodrigues, Joana Ramos; Donato, Helena Margarida de Miranda Lemos Romão; Azevedo, Soraia Raquel Loureiro; Pires, Luís Miguel da SilvaBackground: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, structural damage, and disability. Methotrexate (MTX) is the first-line treatment; however, up to one-third of patients exhibit an inadequate response. This systematic review aimed to identify clinical, serological, genetic, pharmacogenomic, and treatment-related predictors of MTX response in RA. Methods: ...
A Regression-Based Model for Estimating the Lower Heating Value of Fuels from E...
Castro, Carlos; Gonçalves, Margarida; Pacheco, Nuno; Teixeira, José CarlosThe lower heating value (LHV) is one of the most important fuel properties in thermochemical conversion systems, directly affecting energy balances, process efficiency, and fuel selection. Although several empirical correlations have been proposed in the literature, most existing models are limited to specific fuel classes or focused primarily on higher heating value (HHV) prediction. In this work, generalized ...
Elaboração do Plano de Mobilidade Urbana Sustentável da Cidade de Lisboa: a apl...
Lima, Larissa Tomasio deDesde 2013, a União Europeia (UE) e o governo nacional vêm intensificando esforços para que as autarquias adotem Planos de Mobilidade Urbana Sustentável (PMUS). A promessa central é a melhoria do desempenho e a eficiência dos sistemas de mobilidade: reduzindo o congestionamento e o ruído rodoviário e elevando a segurança, a fruição do espaço público e a procura por modais suaves e ativos, com ganhos para a qual...
The social stock exchange: A quantitative exploration
Alvarez, Ana Catarina Silva DiasWe introduce the Social Stock Exchange (SSE), by presenting its work, structure and brief history. The main goal of the SSE is to promote accountability and transparency in the relationship between the donors (Social Investors) and NGOs, which allows for a privileged access to data and information about the projects listed. Hence, this study exploits all the information made available by the SSE and constructs ...
Inventory Management for the Health Sector: ABC Analysis Approach
Nabais, Joana Isabel BaptistaThis project aims to analyse a hospital’s inventory management and make suggestions to improve its practices, with special attention on ABC analysis as an optimization tool for the inventory management, control and storage. Other cost reductions approaches are studied in order to contribute for the accurate management of clinical consumption materials. Wide efficient use of information and communication technol...
PON1 haplotypes show genotype-dependent associations with dysglycemia and metab...
Batista-Herrera, Laura; Meneses, Maria João; Ribeiro, Rogério T.; Gardete-Correia, Luís; Raposo, João F.; Boavida, José Manuel; Penha-Gonçalves, CarlosIntroduction – Paraoxonase 1 (PON1) is a liver-derived HDL-associated enzyme with key antioxidant functions implicated in cardiometabolic disease. Genetic variation in PON1 strongly influences enzyme activity; however, whether specific genetic configurations contribute to dysglycemia and metabolic liver risk beyond enzymatic activity remains unclear. Methods – We analyzed 922 individuals from the PREVADIAB2 coh...
Nestum vs private labels: a renewed identity for Nestum
Andrade, Carla Andreia Rosa Duarte Teixeira deThis research has the main goal to recommend a renewed brand identity for Nestum, the leader in the milk & cereals’ segment, to face the growing competition of private labels in this segment which are gaining market share at Nestum expense. To reach this renewed identity a detailed market analysis including nutritional information of products will be performed, including also the brand audit and the brand image...