3122043 documents found, page 312174 of 312205
Prunus avium L. (Sweet Cherry) By-Products: A Source of Phenolic Compounds with...
Nunes, Ana R.; Gonçalves, Ana C.; Falcão, Amílcar; Alves, Gilberto; Silva, Luís R.Prunus avium L. (sweet cherry) is one of the most appreciated fruits due to its organoleptic and nutritional value. Interestingly, cherry leaves, stems, and flowers are agri-food by-products rich in bioactive compounds that are mostly still unexploited. Stems and leaves have been used in folk medicine since ancient times. Recently, cherry flowers have also proved to be an interesting source of compounds with th...
The Role of Learning and Communication Technologies in Online Courses’ Design a...
Meletiou-Mavrotheris, Maria; Mavrou, Katerina; Rebelo, Piedade VazThis article presents the results of a study, conducted within the scope of the EU-funded project RELOBIE: Reusable Learning Objects in Education, which investigated faculty perceptions and practices regarding the educational use of contemporary and emerging technologies. A cross-national, in-depth online survey of n = 171 faculty members in the four partner countries (Estonia, Cyprus, Norway, Portugal) took pl...
As finanças da Câmara Municipal de Coimbra nos finais do Antigo Regime (1762-18...
Barbosa, José Luís dos SantosO presente estudo pretende analisar a estrutura e evolução da despesa da Câmara Municipal de Coimbra, entre 1762 e 1820. Para tal, aspira-se à criação de uma tipologia de categorização da despesa municipal na Época Moderna, que permita a sua implementação em investigações futuras sobre finanças municipais. Pretendemos compreender em que medida a composição e a evolução da despesa foi afetada pela evolução da re...
Civil society organisations and gender equality
Lopes, Mónica; Ferreira, Virgínia; Ferreira, Sílvia; Coelho, LinaIn this presentation we propose a framework for the analysis of the role of civil society and third sector organisations in gender equality that articulates two analytical and empirical axes. On one hand, mainstreaming, related to the practices regarding equality between women and men both inside and outside organisations, including governance structures, the labour force and the volunteers, as well as activiti...
Synthesis, in vitro evaluation and QSAR modelling of potential antitumoral 3,4-...
Matias, Mariana; Campos, Gonçalo; Santos, Adriana O.; Falcão, Amílcar; Silvestre, Samuel; Alves, GilbertoA series of 3,4-dihydropyrimidin-2-(1H)-thiones (1–22) was synthesized through the Biginelli reaction in order to find novel anticancer drug candidates based on the structure of monastrol. The antiproliferative activity of the compounds was screened in several cell lines and the chlorinated compounds expressed considerable cytotoxicity in hepatic and/or colon and MCF-7 breast cancer cell lines. Within these, co...
Insights into the mechanisms of intracellular delivery of targeted liposomal do...
Cruz, Ana Filipa Fernandes daCancer is one of the leading causes of death worldwide and responsible for an estimated 10 million deaths in 2020. Among them, female breast and ovary represented 6.9% and 2.1%, respectively, of the total of cancer deaths in 2020. Tumor development and progression relies on a complex signaling network of deregulated pathways, as the PI3K/Akt pathway, sustaining cell proliferation, growth and survival. Additiona...
Stable Isotope Dynamics (δ13C and δ15N) in Neritic and Oceanic Waters of the No...
Ceia, Filipe R.; Cherel, Yves; Paiva, Vítor; Ramos, Jaime A.Intrinsic markers, such as stable isotopes, are a powerful approach to trace wildlife movements because they do not require initial marking of the organism. The main limitation of the isotopic method is the lack of knowledge in spatio-temporal patterns and dynamics of stable isotopes in marine environments, especially at local scales. Here, we combine GPS-tracks and isotopic signatures from Cory’s shearwaters a...
Considerations and Pitfalls in Selecting the Drug Vehicles for Evaluation of Ne...
Matias, Mariana; Silvestre, Samuel; Falcão, Amílcar; Alves, GilbertoPurpose - During the discovery and development of new drugs, compounds with low aqueous solubility pose special challenges in their pharmacological evaluation and, therefore, the selection of appropriate vehicles to administer the compounds of interest is determinant for the quality of the results generated during the in vivo non-clinical studies. This work aimed to evaluate the motor deficit (as a surrogate of...
A new monopole antenna in the form of double dollar-symbol for WLAN (5.1- 6 GHz...
Sabbar, Nisrin; Hati, Khalid; Asselman, Hassan; Hajjaji, Abdellah ElIn this paper, we present a new monopole antenna design for WLAN (5.1-6 GHz) application. The proposed antenna fed by a microstrip and the radiating element is in the form of a double dolar-symbole. The antenna designed is printed on a partial ground plane, and the resulting antenna has been found to possess a compact size of 20 mm × 20 mm, and covers specific bands from the frequency spectra. A parametrical st...
Fatigue Strength Evaluation of Resin-Injected Bolted Connections Using Statisti...
Correia, José António Fonseca de Oliveira; Pedrosa, Bruno Alexandre Silva; Raposo, Patrícia Cordeiro; De Jesus, Abílio Manuel PinhoDifferent strategies can be used to perform reparations and reinforcements of ancient bolted and riveted metallic bridges. As the riveting process is not currently a common practice, it requires proper equipment and skilled workers. Another solution is the use of welding. However, the weldability of old steels is poor. Bolts are very attractive alternative solutions, and are most commonly used to repair old met...