3122043 documents found, page 312184 of 312205
Amyloid–ß peptides interaction with curcumin:AFM and electrochemical characteri...
Chiorcea-Paquim, Ana Maria; Machini, Wesley Bruno S.; Brett, A. M. OliveiraThe naturally occurring polyphenol curcumin found in turmeric has strong affinity for binding to amyloid beta (Aβ) peptides, a key feature of Alzheimer's disease pathology. Its structure allows curcumin to interact with the hydrophobic regions of Aβ peptides, which are crucial for β-sheet formation, inhibiting Aβ aggregation and fibril formation, destabilizing existing plaques, and reducing neurotoxicity. The t...
Mesoporous silica-glycopolymer hybrid nanoparticles for dual targeted chemother...
Cordeiro, Rosemeyre A.; Oliveira, Daniel; Santo, Daniela; Coelho, Jorge; Faneca, HenriqueThe development of nanocarriers for pharmaceutical applications is a challenging research field as they have to fulfil several requirements, such as suitable physicochemical properties, biocompatibility, loading capacity for therapeutic agents, high stability in the bloodstream, and specific delivery to the target cells. This task becomes even more difficult when trying to transport two different therapeutic ag...
Water Networks Management: Assessment of Heuristic and Exact Approaches for Opt...
Cunha, Maria da Conceição Morais de Oliveira; Marques, João; Creaco, EnricoThis paper deals with the optimal design-for-control of water distribution networks (WDNs) with the objectives of minimizing pressure-induced background leakage and maximizing resilience. This problem entails defining locations for installing valves and/or pipes and for simultaneously determining valve settings and belongs to the class of non-convex mixed-integer nonlinear problems. Solving highly complex infra...
Eco-friendly cellulose/TiO₂-hydroxyapatite films for biomedical applications
Devesa, Susana; Benzarti, Zohra; Costa, Madalena Formigal Cardoso da; Carvalho, Diogo Albano Cavaleiro Ventura de; Faia, Pedro M.; Carvalho, SandraIn this work cellulose/TiO2 flexible films coated with hydroxyapatite, aiming the development of electro-active orthopaedic scaffolds, were produced, applying sustainable procedures. The TiO2 nanoparticles were incorporated into the cellulose, extracted from potato peel, and the films were fabricated by the casting method. The hydroxyapatite, synthesized by the sol-gel technique, was electrodeposited onto the c...
Liberdade, Igualdade e Amor: Elementos para uma ética em Nicolau de Cusa
Souza, Klédson Tiago Alves deA presente dissertação propõe-se investigar e explicitar os elementos de uma ética presente na obra de Nicolau de Cusa (1401–1464), de modo a articular fundamentalmente os conceitos de liberdade, igualdade e amor a partir do prisma normativo da conceção de conjectura, como um primeiro momento normativo na conceção do homem como tarefa e viva imago Dei no pensamento deste autor. Partindo do princípio de que o au...
Bright Clues: Fluorescence as a method for detecting skeletal remains with heat...
Silva, Maria Beatriz Barreiro Gama daFire-related contexts, especially large-scale ones such as wildfires, represent a challenging and increasingly important area of intervention for forensic anthropology. One of the main difficulties in these scenarios is the recovery of skeletal remains due to the heat-induced changes they present. Their recovery and analysis require specialised knowledge while also relying on the expert’s experience. Nonetheles...
"Onde estiverem dois ou três reunidos em meu nome": confrarias e irmandades de ...
Campos, Filipe Miguel de AndradeThe confraternal movement in the city of Coimbra has never been the subject of a systematic study. This thesis seeks to answer the following central question: what was the composition of Coimbra's confraternal network during the Modern Period, and what dynamics characterized these institutions? This inquiry unfolds into several others: how did this confraternal network evolve throughout the period under analysi...
Moving electrons and displacing atoms in electron transfer reactions
Prata, Amílcar DuqueThis thesis presents a comprehensive investigation of electron transfer reactions, systematically integrating theoretical foundations, computational methodologies, and experimental validation. The work aims to develop an integrated understanding of how molecular structure, electronic properties, and environmental factors collectively govern electron transfer dynamics in intramolecular and coordination systems.A...
From Copy Number Variations to Biological Networks: Integrating Relational Data...
Santos, André FerreiraCopy number variations (CNVs) are critical to understand the genetic architecture of neurodevelopmental disorders such as autism spectrum disorder (ASD) and developmental delay (DD). This thesis advances a structured computational framework to transform heterogeneous SFARI Gene CNV data into analysis-ready resources, enabling systematic exploration of genotype-phenotype relationships. First, we developed a rela...
Energia e Prática Culinária no Século XX em Portugal - Do carvão à eletricidade...
Morais, Sandra Mónica da Rocha FernandesThis thesis analyses the relationship between culinary practices and energy transitions in Portugal throughout the twentieth century, taking Lisbon as a privileged case study. Its central objective was to understand how the shift from firewood and coal to gas and electricity, accompanied by the spread of new domestic appliances, reconfigured or preserved culinary practices and shaped the continuity of tradition...