3125265 documents found, page 312290 of 312527
Microvascular anatomy and mapping of intraosseous arterioles in the human L1 ve...
Moura, Diogo Lino; Casal, Diogo; Alves, Sara; Pinto, Dora; Ramos, Solange; Alves, Ana Lúcia; Almeida, Rui; Pais, Diogo; Bernardes, AntónioBackground: Post-traumatic vertebral necrosis is a challenging and unpredictable complication in spinal trauma, believed to result from ischemic injury due to vascular damage at the time of fracture, though this remains unproven. This study aims to provide a detailed anatomical description of the arterial microvasculature of the human L1 vertebral body, based on sequential histological analysis. Methods: Three ...
Thrombocytopenia in carriers and patients with antiphospholipid syndrome
START-A. P. S. Investigators^Patients with thrombotic antiphospholipid syndrome (APS) or subjects with persistent presence of antiphospholipid antibodies (aPLA), defined “carriers”, may develop thrombocytopenia. However, the prevalence and clinical characteristics associated with thrombocytopenia remain poorly understood. We aimed to describe the prevalence and the clinical characteristics associated with thrombocytopenia in APS patients a...
Effects of digoxin in modern heart failure treatment
Valentim Gonçalves, António; Cardim, Nuno; Fiarresga, António; Pereira-da-Silva, Tiago; Ilhão-Moreira, Rita; Galrinho, Ana; Rio, PedroAims: Even though it is the oldest heart failure (HF) medication still in use, digoxin has not been evaluated alongside the updated algorithm for treating HF with reduced ejection fraction patients. This could help explain the low use of digoxin in recent HF studies. The main objective is to assess the effectiveness of digoxin in functional capacity and cardiac function when combined with modern HF therapy. Met...
Therapy Optimization in mHSPC
Mansinho, André; Gramaça, João Carlos; Ramos, Rodrigo; Baltazar, Pedro Miguel; Palma dos Reis, José; Fernandes, Ricardo; Malheiro, MarianaMetastatic hormone-sensitive prostate cancer (mHSPC) is a disease state characterized by the presence of distant metastases detectable on conventional imaging while the tumor remains responsive to androgen deprivation therapy (ADT). It represents an earlier, treatment-sensitive phase that precedes the development of metastatic castration-resistant prostate cancer (mCRPC), the terminal stage of the disease. The ...
Multi-stage phase-resolved conjugate heat-transfer analysis of an isobutane (R6...
Vásquez, J.; Cleto, D.; Garcia, J.; Lança, M.; Conde, J. M. P.This work presents a multi-stage Computational Fluid Dynamics methodology to analyse the thermal behaviour of a didactic isobutane (R600a) evaporator and support the optimisation of natural-refrigerant cooling systems. Improving evaporator performance with environmentally friendly refrigerants requires quantifying the relative influence of solid material properties and two-phase heat-transfer mechanisms, which ...
IFAA Recommendations for good practice for the donation and anatomical study of...
Jones, D. Gareth; Champney, Thomas H.; Hildebrandt, Sabine; Winkelmann, Andreas; Billings, Brendon; Ghosh, Sanjib K.; Gürses, İlke Ali; Pais, DiogoThe study of human anatomy is foundational to education and research in the anatomical and health sciences. In 2012, the International Federation of Associations of Anatomists (IFAA) first published Recommendations to promote ethical practice in the acquisition of human remains for this purpose. In the intervening period, increased awareness of contemporary ethical issues and challenges in the discipline have m...
Translational insights into extracellular vesicles in peritoneal dialysis
Sequeira, Diogo; Anão, Sofia; Calça, Ana Rita; Matias, Patrícia João; de Melo Junior, Antonio Ferreira; Ferreira, João Vasco; Carvalho, Ana SofiaPeritoneal dialysis (PD) is a cornerstone kidney replacement therapy for patients with end-stage kidney disease; however, chronic exposure to bioincompatible dialysis solutions progressively damages the peritoneal membrane, leading to mesothelial-to-mesenchymal transition, fibrosis, and ultimately ultrafiltration failure. Currently, peritoneal membrane dysfunction is detected only at advanced stages through the...
A Systematic Review of Risk Sources in R&D Project Management
Pais, João Sabino; Tenera, AlexandraThrough a systematic review, the study examines critical sources of risk affecting R&D initiatives. Out of an initial pool of 178 articles, 46 studies were selected for detailed analysis. Key risks identified include technological, financial, and management-related uncertainties. The review evaluates proactive mitigation strategies, such as agile methodologies and scenario planning, tailored to the distinct cha...
Protocol for semi-automatic quantitative bioimaging analysis of synapse loss
Barata, Mariana A.; Guimas Almeida, CláudiaSynapse loss correlates with cognitive decline in neurodegenerative diseases like late-onset Alzheimer’s disease. We developed a semi-automated workflow to quantify synapse loss in primary mouse neurons. The protocol includes culturing neurons on coverslips, using short hairpin RNA (shRNA)-expressing lentivirus, maintaining cultures, and labeling excitatory and inhibitory presynaptic markers by immunofluorescen...
Adaptive OEE
Anes, Vitor; Marques, Pedro; Abreu, AntónioOverall Equipment Effectiveness (OEE) measures manufacturing productivity as the product of Availability (A), Performance (P), and Quality (Q). Despite its widespread adoption, the classical OEE formula embeds a structural limitation, i.e., the three components are treated as equally important regardless of operational context. This fixed-weight assumption distorts maintenance prioritisation in environments whe...