3125766 documents found, page 312413 of 312577
Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidru...
Ferreira, Ana; Rodrigues, Márcio; Fortuna, Ana; Falcão, Amílcar; Alves, GilbertoThe pharmacoresistance to antiepileptic drugs (AEDs) remains a major unsolved therapeutic need. The overexpression of multidrug transporters, as the P-glycoprotein (P-gp), at the level of the blood-brain barrier of epileptic patients has been suggested as a key mechanism underlying the refractory epilepsy. Thus, efforts have been made to search for therapeutically useful P-gp inhibitors. Herein, the strategy of...
Existence of periodic solutions of a periodic SEIRS model with general incidence.
Mateus, Joaquim; Silva, CésarFor a family of periodic SEIRS models with general incidence, we prove the existence of at least one endemic periodic orbit when some condition related to R0 holds. Additionally, we prove the existence of a unique disease-free periodic orbit, that is globally asymptotically stable when R0 < 1. In particular, our main result generalizes the one in Zhang et al. (2012). We also discuss some examples where our resu...
Horizontal and Vertical Handheld Pointing Devices Comparison for Increasing Hum...
Lourenço, Miguel; Pitarma, Rui; Coelho, DenisIn addition to postural and biomechanical aspects related to usage of handheld pointing devices it is also important to perform usability assessment. The paper reports on an experimental study comparing two computer pointing devices, a standard horizontal PC mouse and a vertical device (for neutral pronation of the forearm), both commercially available. The standardized tasks implemented by software and perform...
UP in the Clouds: Where to Find to Enhenced Learning
Gomes, Natália; Ribeiro, María del Carmen; Serrano, María JoséThis research review reports on articles presenting empirical research in the area of how the learning and teaching process, involving teachers, students, and learning institutions, can be enhanced by the use of technology, particularly through the use of the new opportunities offered by cloud services. Some studies have demonstrated that the implementation of blended and mobile learning can modify and create n...
Using a Triple Helix approach to examine interactions and dynamics of innovatio...
Natário, Manuela; Braga, Ascensão; Daniel, Ana; Rosa, Cecília; Salgado, MiguelUsing the Triple Helix model, this article examines the contribution of a higher education institution, the Polytechnic of Guarda (PG), located in an inland, a less-favoured region of Portugal, to territorial innovation dynamics. The main goal is to explore how the interaction and cooperation between the three helices of the Guarda region (PG, companies and local governance institutions) fosters innovation and ...
GPUMLib: Deep Learning SOM Library for Surface Reconstruction
Lee, Wai; Hasan, Shafaatunnur; Shamsuddin, Siti; Lopes, NoelThe evolution of 3D scanning devices and innovation in computer processing power and storage capacity has sparked the revolution of producing big point-cloud datasets. This phenomenon has becoming an integral part of the sophisticated building design process especially in the era of 4th Industrial Revolution. The big point-cloud datasets have caused complexity in handling surface reconstruction and visualizatio...
Trading off Distance Metrics vs Accuracy in Incremental Learning Algorithms
Lopes, Noel; Ribeiro, BernardeteWith the growth and development of data, the empirical evidence supporting a link between the distance metrics that are used in the instance-based algorithms and generalization has been mounting. In this paper, we look at distinct similarity measures to study its impact on the performance accuracy of incremental instance-based algorithms in pattern recognition problems. An in-depth analysis of the results of th...
On Combining Diverse Static Analysis Tools for Web Security: An Empirical Study
Nunes, Paulo; Medeiros, Ibéria; Fonseca, José; Neves, Nuno; Correia, Miguel; Vieira, MarcoDevelopers frequently rely on free static analysis tools to automatically detect vulnerabilities in the source code of their applications, but it is well-known that the performance of such tools is limited and varies from one software development scenario to another, both in terms of coverage and false positives. Diversity is an obvious direction to take to improve coverage, as different tools usually report di...
LA INCLUSIÓN EDUCATIVA Y SOCIAL DESDE UNA PERSPECTIVA PORTUGUESA Projeto-TELESE...
Tadeu, PedroO espírito positivo de uma Educação Inclusiva pode e deve ser visto de diferentes perspetivas ao longo do tempo e dependendo claramente do espaço. Vivemos no século XXI e podemos agora olhar para o futuro com a noção do passado que percorrermos e do que ainda falta para proporcionar a todos uma verdadeira possibilidade de participação na sociedade em que vivemos. Este simpósio pretende partilhar um pouco da vis...
Patologias de edifícios históricos tombados: Estudo de caso – Convento das Mercês
Carvalho, Wadson MayckelA cidade de São Luís, no estado do Maranhão, Brasil é considerada uma das mais representativas configurações urbanas arquitetônicas produzidas pela colonização portuguesa. O Convento das Mercês é um prédio histórico construído em 1654 que representa bem essa arquitetura, pelos seus arcos e estrutura com pedras argamassadas e faz parte do Patrimônio Histórico e Cultural Brasileiro em São Luís. Tal como outros mo...