3136533 documents found, page 313639 of 313654

Reflexões sobre a inatividade física e a importância do exercício físico na mel...

The neural correlates of emotion in family dyads

As emoções surgem em resposta a sinais internos e externos, desempenhando uma função adaptativa que guia o comportamento. Contudo, quando as emoções não são adequadas ao contexto, podem tornar-se mal-adaptativas, salientando a importância de competências como a regulação emocional (RE) e a empatia. O ambiente familiar desempenha um papel importante no desenvolvimento emocional. Os pais contribuem para o desenvo...

Cell Free DNA Fragmentomics as an Innovative Tool for Risk Stratification of HP...

Introduction. Cervical cancer screening based on human papillomavirus (HPV) detection has limited specificity for distinguishing transient from persistent infections with transforming potential. The detection of cervical intraepithelial neoplasia through blood-based liquid biopsy remains challenging because systemic dissemination of viral DNA during these precursor stages is uncertain. In this context, this pil...

Co-regulation of Biofilm Formation and Antimicrobial Resistance in Acinetobacte...

Multidrug-resistant Acinetobacter baumannii is now recognized as a major global threat to healthcare systems. This pathogen exhibits resistance to multiple last-resort antibiotics and readily acquires and disseminates antimicrobial resistance (AMR) genes. Its high disease severity and global clinical burden led the World Health Organization (WHO) to classify A. baumannii as a critical-priority pathogen in the 2...

Targeting Nitric Oxide Pathways with Dietary Nitrate to Preserve Neurovascular ...

Preserving cognitive function in aging and metabolic disease represents a major clinical and societal challenge, given the growing burden of dementia and the limited availability of effective disease-modifying therapies. Increasing evidence indicates that impairment in neurovascular coupling (NVC) plays a central role in this process by disrupting the precise matching between neuronal activity and cerebral bloo...

Processos Catalíticos Sustentáveis para o Desenvolvimento de Polímeros Fotossen...

The development of advanced polymeric materials with photosensitive properties has gained increasing attention due to their potential in technological and biomedical applications. In this context, the exploration of sustainable synthetic methodologies is particularly relevant, especially those based on the use of carbon dioxide (CO₂) as a renewable feedstock.This doctoral thesis focuses on the development of ca...

Integrated Wire Arc Additive Manufacturing System for Steel Structures: Control...

O fabrico aditivo (FA) é um processo de fabrico em rápida evolução que permite a produção de componentes que combinam inovações em materiais, processos, sistemas e design geométrico. Os métodos de fabricação por directed energy deposition (DED), como por exemplo fabrico aditivo por soldadura a arco elétrico (WAAM) e por soldadura a laser (LMD), estão a ganhar interesse, tanto no meio académico como na indústria...

Rádio-223 no cancro da próstata metastático: a procura por mais evidências além...

Radionuclide therapy has been presenting an increasingly important role in cancer treatment. Radium dichloride (²²³RaCl₂) was the first predominantly alpha emitter approved for clinical use, specifically in the treatment of castration-resistant metastatic prostate cancer with bone exclusive metastases. However, its therapeutic efficacy remains limited and highly variable among patients due to insufficient under...

Eles Morreram, Elas Não: Um estudo sobre a viuvez feminina

In Portugal, the demographic prevalence of widowhood among women aged over 65 underscores the extent to which conjugal loss constitutes a markedly feminised experience. Despite the growing and increasingly significant representation of older people within the portuguese demographic structure, and given the clear analytical relevance of examining their lived experiences, both later life and widowhood remain insu...

Biomimetic cell membrane-camouflaged vitamin-based nanoparticles for improved p...

O adenocarcinoma ductal pancreático (PDAC) é uma neoplasia altamente agressiva, frequentemente diagnosticada em estádios avançados devido à ausência de sintomas específicos e ao desenvolvimento precoce de metástases. Atualmente, a quimioterapia sistémica constitui a principal opção terapêutica para doentes com PDAC metastático. No entanto, a elevada heterogeneidade genética e o tecido conjuntivo denso caracterí...