3136533 documents found, page 313644 of 313654

Microfluidic paper-based devices for public health biomarkers monitoring

To develop rapid, disposable sensors for biomarkers assessment in biological fluids of non-invasive collection, natural waters and food samples was the driving force of the project PHsense – Design and development of disposable, user-friendly microfluidic sensors to monitor Public Health indicators in a One Health approach. The idea was to produce fast-response and accurate sensor devices to enable reliable and...

Transcription termination factor 2 (TTF2) prevents premature rRNA synthesis dur...

Mitosis poses major challenges to transcription, as gene expression is silenced and must be restored upon mitotic exit. These processes are regulated by Cdk1-dependent phosphorylation. Additional mechanisms, including transcription termination factor 2 (TTF2)-mediated removal of nascent transcripts, reinforce transcriptional shutdown. How these regulatory layers control different RNA polymerases and influence r...

Uso problemático da internet numa amostra de estudantes universitários: resulta...

A propósito de Daniel Serrão, aqui diante de mim

Coaxial 3D printing of core-shell inks: a synergistic approach to mechanically ...

Meniscus injuries are among the most prevalent musculoskeletal disorders and a major risk factor for the development and progression of knee osteoarthritis. The intrinsic healing capacity of the meniscus is severely limited, particularly in the inner avascular region, where approximately 70% of lesions occur, restricting the effectiveness of current surgical repair strategies. Although regenerative approaches h...

Accelerating requirement collection for software projects with AI : challenges ...

Requirement collection in enterprise software projects suffers from a persistent sensing gap in which stakeholder needs remain latent or miscommunicated until late project stages, generating rework and cost overruns. Despite generative AI tools capable of producing provisional solution artefacts rapidly, systematic integration into Sprint 0 workflows remains limited. This study investigates how integrating AI-g...

Starts Vertigo residencies as infrastructures of care: supporting artistic and ...

This paper examines the VERTIGO–STARTS artistic residency programme (2016–2020) as a structured infrastructure of care for artists, technologists, researchers, and communities engaged in art–science–technology collaboration. Moving beyond a narrative centred solely on technological innovation or economic impact, this study argues that residencies function as relational and organisational systems that distribute...

Comunicação organizacional em transformação: da escola clássica à era da plataf...

Nas últimas décadas, as organizações têm vindo a vivenciar transformações profundas, impulsionadas pela crescente digitalização, pela plataformização da sociedade e pelo desenvolvimento da inteligência artificial (IA). O presente estudo procura responder a duas questões de investigação: de que forma o campo da Comunicação Organizacional, desde o seu legado clássico até às novas formas organizacionais, se reconf...

Encenação e meta-narrativa no cinema de animação

Tendo como objetivo a compreensão dos desdobramentos metalinguísticos da curta-metragem Betty (2020), de Will Anderson, consideramos neste artigo o modo como o cinema de animação representa os seus processos de criação e de que maneira a sua linguagem pode ultrapassar os seus próprios limites. A utilização de metalinguagem no cinema de animação remonta ao seu início: tanto em Humorous Phases of Funny Faces (190...

Genetic testing and reporting: what the endocrinologists should know and can ex...

Over the last decade, next-generation sequencing (NGS) has become an essential tool for diagnostic DNA testing in human genetics. To improve the understanding of available genetic testing strategies and to facilitate the request of genetic testing in daily endocrine practice, clinical and laboratory experts in the field have summarized the major issues which should be known and considered. In this joint positio...