As citopenias são uma manifestação clínica frequente da mielofibrose, entre as quais se destaca a anemia. Embora a correção das citopenias seja fundamental para melhorar o prognóstico e a qualidade de vida dos doentes com mielofibrose, existem poucas opções terapêuticas eficazes. Além disso, não há recomendações nacionais para gestão das citopenias na mielofibrose. Com o objetivo de colmatar esta lacuna, um pai...
O medo, estado psicológico e mecanismo natural, está inscrito de forma indelével no mais profundo do nosso ser, mas, por força da aprendizagem e da cultura, pode sofrer alterações nas suas formas de expressão e no seu significado. Quando saudável, pode ser uma chamada para a ação, mas, quando se torna crónico, mesmo que não patológico, afeta a nossa capacidade de desenvolvimento e crescimento pessoal, a nossa r...
Knee meniscus lesions are a common injury that significantly impact an individual's quality of life. Meniscus tissue lack of intrinsic regenerative capacity requests efficient treatments that simultaneously offer robust mechanical integrity and promote rapid tissue integration. Current treatments fail in long-term, accelerating osteoarthritic changes in the knee [1]. To address the inherent trade-off between st...
“Where there is power, there is resistance, and yet, or rather consequently, this resistance is never in a position of exteriority in relation to power”(Foucault 1978, 95). The social, political and economic power dynamic between rulers and subjects in one that transcends time. Only the dimensions in which such dynamic develops changes, and the correlation between the two is undissociated. Simultaneously, as a ...
Background: Early intervention programmes increasingly use eHealth components to extend family-centred support beyond neonatal intensive care unit discharge. However, their effectiveness on parental and infant health outcomes during the transition from neonatal intensive care unit to home remains unclear. Objective: To assess the effectiveness of eHealth early intervention programmes supporting parents of prete...
Phonological awareness in sign languages, essential for the linguistic development of signing deaf children, is an emerging field of research. The analysis of scientific advances and research gaps in this area, particularly in Portuguese Sign Language (Língua Gestual Portuguesa, LGP), highlights the need to map its central concepts, methodologies, and challenges. The phonological parameters of sign languages: h...
Problem: Hope is central to perinatal support, but encouragement may become a demand to appear positive after an adverse prenatal diagnosis. Background Women can hold hope alongside fear and grief. Existing approaches rarely examine what happens when hope becomes socially required, or what its display is expected to prove. Aim: To explain the conditions under which hope becomes a performative obligation for wom...
Correction to: Journal of Materials Science: Materials in Medicine https://doi.org/10.1007/s10856-019-6225-y In this article the figure 2, AFM images corresponding to SF/PVA and SF/GLY membranes with 10% synthetic polymer content and dried for 6 hours are identical and result from an accidental duplication during figure preparation due to its similarity. We have now corrected Figure 2 by replacing the duplicate...
The present study investigated the effects of goat yogurt supplemented with Opuntia ficus-indica (OFI) powder on behavioral parameters, brain oxidative stress, fecal metabolomic and volatilomic profiles, and gut microbiota in young Wistar rats. Thirty male rats were assigned to three groups (n = 10): control (CG), goat yogurt (GY), and goat yogurt supplemented with OFI (CGY), treated orally for 30 days. Behavio...
AI companions-chatbots using Large Language Models to simulate human interaction–mark a shift toward AI designed for virtual social and emotional connection. While some studies suggest these tools can reduce loneliness, their rise raises serious ethical, philosophical, and societal concerns, particularly around young people. This essay introduces the key issues at stake and explores how the Social Doctrine of t...