Publicação
Aspetos hematológicos do envelhecimento
| Resumo: | Aging and illness are not synonymous, but with aging, anatomical and physiological changes occur and make elderly most vulnerable to an onset of various diseases. Anaemia is a hematologic disease quite common in the elderly and has been subdivided into four types, anaemia by nutritional deficiencies, anaemia of chronic inflammation, anaemia of chronic kidney disease and unexplained anaemia. Anemia has many adverse consequences in the elderly, increasing morbidity and mortality. Thus, the appropriate diagnosis and treatment of each type of anaemia allows to minimize these adverse consequences and to improve the quality of life in these patients. The vascular, renal and hematopoietic changes, as well as, the wild chronic proinflammatory state, that are associated with the aging process, in combination with comorbidities and a genetic predisposition, favor the development of anaemia in this population. In this paper we performed a review of the main etiologies associated with anaemia in the elderly, and discusse its pathophysiology. |
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| Autores principais: | Andrade, Rita |
| Outros Autores: | Costa, Elísio; Santos-Silva, Alice |
| Assunto: | anaemia aging inflammation hematopoiesis renal disease. anemia envelhecimento inflamação hematopoiese doença renal |
| Ano: | 2012 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Instituição associada: | Ordem dos Farmacêuticos do Porto |
| Idioma: | português |
| Origem: | Acta Farmacêutica Portuguesa |
| Resumo: | Aging and illness are not synonymous, but with aging, anatomical and physiological changes occur and make elderly most vulnerable to an onset of various diseases. Anaemia is a hematologic disease quite common in the elderly and has been subdivided into four types, anaemia by nutritional deficiencies, anaemia of chronic inflammation, anaemia of chronic kidney disease and unexplained anaemia. Anemia has many adverse consequences in the elderly, increasing morbidity and mortality. Thus, the appropriate diagnosis and treatment of each type of anaemia allows to minimize these adverse consequences and to improve the quality of life in these patients. The vascular, renal and hematopoietic changes, as well as, the wild chronic proinflammatory state, that are associated with the aging process, in combination with comorbidities and a genetic predisposition, favor the development of anaemia in this population. In this paper we performed a review of the main etiologies associated with anaemia in the elderly, and discusse its pathophysiology. |
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